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Modulation of protein-protein interactions: The role of short peptides in modulating protein-protein interactions in-vivo - Tapa blanda

Dar, Altaf

 
9783843361781: Modulation of protein-protein interactions: The role of short peptides in modulating protein-protein interactions in-vivo
Tapa blanda
ISBN 10: 3843361789 ISBN 13: 9783843361781
Editorial: LAP LAMBERT Academic Publishing, 2010

Sinopsis

Interaction of proteins is central to various cellular processes like cell growth, proliferation, differentiation and programmed cell death. To study the specific role of a single protein-protein interaction of a multifunctional protein or protein complex, it is necessary to interrupt each single interaction individually to elucidate their respective role and influence they exert. In this study two approaches were employed to modulate protein interactions. First one was to target a known protein-protein interaction by expressing specific peptides in vivo. The second one was based on the LXXLL motif to disrupt interactions between transcription factors and coactivators.

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Reseña del editor

Interaction of proteins is central to various cellular processes like cell growth, proliferation, differentiation and programmed cell death. To study the specific role of a single protein-protein interaction of a multifunctional protein or protein complex, it is necessary to interrupt each single interaction individually to elucidate their respective role and influence they exert. In this study two approaches were employed to modulate protein interactions. First one was to target a known protein-protein interaction by expressing specific peptides in vivo. The second one was based on the LXXLL motif to disrupt interactions between transcription factors and coactivators.

Biografía del autor

Altaf A Dar is currently working on identifying biomarkers involved in melanoma progression and metastasis at CPMC, San Francisco, CA. Previously Dr. Dar worked on gastric cancer at Vanderbilt University, Nashville, TN. Dr. Dar earned his PhD from Friedrich Schiller University, Jena Germany, where he worked on protein-protein interactions.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2010
Idioma
Inglés
ISBN 10 
3843361789
ISBN 13 
9783843361781
Encuadernación
Tapa blanda
Número de páginas
96
Contacto del fabricante
no disponible
Persona responsable
no disponible