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R-Ras Proteins, TGF-Beta and Cancer: Mechanisms of Interaction Among the R-Ras, TC21 and TGF-Beta Signaling Pathways - Tapa blanda

Erdogan, Mete

 
9783838306643: R-Ras Proteins, TGF-Beta and Cancer: Mechanisms of Interaction Among the R-Ras, TC21 and TGF-Beta Signaling Pathways

Sinopsis

During the progression of human cancers, normal cells acquire genetic and epigenetic changes in the signaling pathways that govern their proliferation, resulting in uncontrolled growth and tumor formation. Oncogenic Ras and Transforming Growth Factor-Beta are known to cooperate in promoting malignant transformation, yet the mechanism by which they interact has not been established. Here, we present novel mechanisms through which Transforming Growth Factor-Beta interacts with two Ras-related proteins, R-Ras and TC21, to transform mammary epithelial cells.

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Reseña del editor

During the progression of human cancers, normal cells acquire genetic and epigenetic changes in the signaling pathways that govern their proliferation, resulting in uncontrolled growth and tumor formation. Oncogenic Ras and Transforming Growth Factor-Beta are known to cooperate in promoting malignant transformation, yet the mechanism by which they interact has not been established. Here, we present novel mechanisms through which Transforming Growth Factor-Beta interacts with two Ras-related proteins, R-Ras and TC21, to transform mammary epithelial cells.

Biografía del autor

Mete Erdogan obtained a PhD in Cancer Biology from Vanderbilt University in Nashville, TN (USA). Presently, he is pursuing a Postdoctoral Fellowship in Cancer Biology at Dalhousie University in Halifax, Canada.

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