Quantification of Structural Changes in the Brain: using Magnetic Resonance Imaging - Tapa blanda

Fritzsche, Klaus Hermann

 
9783838118765: Quantification of Structural Changes in the Brain: using Magnetic Resonance Imaging
Tapa blanda
ISBN 10: 3838118766 ISBN 13: 9783838118765
Editorial: Südwestdeutscher Verlag für Hochschulschriften, 2010

Sinopsis

Magnetic Resonance Imaging (MRI) and diffusion weighted MRI non-invasively deliver anatomical and even microstructural parameters of the living human brain with ever increasing resolution and detail. This book addresses current main challenges in detecting structural changes in the brain and diagnosing Alzheimer's Disease (AD) at early stages using imaging markers. An automated method for individual patient atrophy assessment on a macroscopic level and a Diffusion Tensor Imaging (DTI) based approach to fiber integrity assessment on a microscopic level are introduced. Diffusion phantoms are presented that allow the controlled investigation of quantification methods under PV conditions. A comprehensive set of in-vivo, in-vitro, and in-silico experiments are defined and applied to evaluate different existing and novel DTI- and Q-ball imaging based measures of brain integrity. The presented methods and findings improve the understanding, applicability, and diagnostic use of recently proposed imaging techniques and are an essential step as well towards clinical application of quantitative imaging as towards computer assisted early AD diagnosis.

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Reseña del editor

Magnetic Resonance Imaging (MRI) and diffusion weighted MRI non-invasively deliver anatomical and even microstructural parameters of the living human brain with ever increasing resolution and detail. This book addresses current main challenges in detecting structural changes in the brain and diagnosing Alzheimer's Disease (AD) at early stages using imaging markers. An automated method for individual patient atrophy assessment on a macroscopic level and a Diffusion Tensor Imaging (DTI) based approach to fiber integrity assessment on a microscopic level are introduced. Diffusion phantoms are presented that allow the controlled investigation of quantification methods under PV conditions. A comprehensive set of in-vivo, in-vitro, and in-silico experiments are defined and applied to evaluate different existing and novel DTI- and Q-ball imaging based measures of brain integrity. The presented methods and findings improve the understanding, applicability, and diagnostic use of recently proposed imaging techniques and are an essential step as well towards clinical application of quantitative imaging as towards computer assisted early AD diagnosis.

Biografía del autor

Klaus Hermann Fritzsche received his Diploma degree in Computer Science from the University of Karlsruhe, Germany, and completed the MSc program at the Federal University of Santa Catarina, Brazil, in 2006. He prepared his PhD-thesis at the German Cancer Research Center and the faculty of computer science at the University of Heidelberg.

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Editorial
Südwestdeutscher Verlag für Hochschulschriften
Año de publicación
2010
Idioma
Inglés
ISBN 10 
3838118766
ISBN 13 
9783838118765
Encuadernación
Tapa blanda
Número de páginas
248
Contacto del fabricante
no disponible
Persona responsable
no disponible