Artículos relacionados a Analysis of Protein-Protein Interactions- A Computational...

Analysis of Protein-Protein Interactions- A Computational Approach - Tapa blanda

Ansari, Sam

 
9783836423090: Analysis of Protein-Protein Interactions- A Computational Approach
Tapa blanda
ISBN 10: 383642309X ISBN 13: 9783836423090
Editorial: VDM Verlag Dr. Mueller e.K., 2007

Sinopsis

In the past years protein-protein interactions have gained a strong interest inthe fields of pharmacy, medicine, biology, and bioinformatics. In this book,statistical information on protein-protein interactions are computationallycollected and analyzed. Characteristic properties are determined and theirpredictability estimated. Therefore, the results from a common dockingapproach are re-evaluated with the collected information to discriminatestructures with high yet biologically meaningless geometric complementarityat the interface region from the near native structures. The results show thatalthough there is a noticeable improvement in the predictability afterapplying statistical information, the overall accuracy is still low. To find othermore specific properties, transient and permanent complexes were comparedto each other. The lack of data led to an extensive search for more suitablestructural data and the development of an extensive database. This databasewas ultimately used to retrieve a large number of protein properties thatwere automatically analyzed for their separation precision. A high accuracywas obtained in separating transient and permanent interactions based onthe combination of only four properties. Combining this information withcommon docking approaches based on geometrical complementarity maylead to satisfying sensitivities.

"Sinopsis" puede pertenecer a otra edición de este libro.

Reseña del editor

In the past years protein-protein interactions have gained a strong interest in the fields of pharmacy, medicine, biology, and bioinformatics. In this book, statistical information on protein-protein interactions are computationally collected and analyzed. Characteristic properties are determined and their predictability estimated. Therefore, the results from a common docking approach are re-evaluated with the collected information to discriminate structures with high yet biologically meaningless geometric complementarity at the interface region from the near native structures. The results show that although there is a noticeable improvement in the predictability after applying statistical information, the overall accuracy is still low. To find other more specific properties, transient and permanent complexes were compared to each other. The lack of data led to an extensive search for more suitable structural data and the development of an extensive database. This database was ultimately used to retrieve a large number of protein properties that were automatically analyzed for their separation precision. A high accuracy was obtained in separating transient and permanent interactions based on the combination of only four properties. Combining this information with common docking approaches based on geometrical complementarity may lead to satisfying sensitivities.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
VDM Verlag Dr. Mueller e.K.
Año de publicación
2007
Idioma
Inglés
ISBN 10 
383642309X
ISBN 13 
9783836423090
Encuadernación
Tapa blanda
Número de páginas
164
Contacto del fabricante
no disponible
Persona responsable
Buchpark GmbH
gpsr@buchpark.de

Krügerweg 1
Trebbin
Brandenburg
14959
Alemania