PEGylated Protein Drugs: Basic Science and Clinical Applications (Milestones in Drug Therapy) - Tapa dura

 
9783764386788: PEGylated Protein Drugs: Basic Science and Clinical Applications (Milestones in Drug Therapy)
Tapa dura
ISBN 10: 3764386789 ISBN 13: 9783764386788
Editorial: Birkhäuser, 2009

Sinopsis

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

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De la contraportada

PEGylated Protein Drugs: Basic Science and Clinical Applications describes the basic technologies and the major results obtained with the PEGylation technique, the covalent binding to proteins, peptides and small organic molecules of the hydrophilic and biocompatible polymer poly(ethylene glycol) to improve their therapeutic efficacy.

The book results from the collaboration of recognized experts from academia and industry, working on various aspects of the PEGylation technology. The first chapters provide general information on the physicochemical, pharmacokinetic, immunogenic and toxicological properties of PEG and PEG-conjugates. The classical and more advanced chemical strategies for linking PEG to protein drugs are described as well as novel enzyme-catalysed approaches. Further chapters are devoted to important PEGylated products, namely PEG conjugates of enzymes, cytokines, antibodies or synthetic organic molecules already on the market or in an advanced state of clinical experimentation. Guidelines for the approval by the Health Agencies of these new nanomedicines are also reported as a last chapter.

Therefore, this book may be a unique instrument for a thorough review of the strategy, advantages and limitations of all aspects of drug PEGylation as well as a stimulation for researchers to develop new exploitations of this technology. It is of interest to physicians, biochemists, pharmacologists and chemists.

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Editorial
Birkhäuser
Año de publicación
2009
Idioma
Inglés
ISBN 10 
3764386789
ISBN 13 
9783764386788
Encuadernación
Tapa dura
Número de páginas
304
Editor
Veronese Francesco M.
Contacto del fabricante
no disponible
Persona responsable
no disponible