Automatic Generation of Process Models for Fed-Batch Fermentations Based on the Detection of Biological Phenomena - Tapa blanda
Resultados de la búsqueda para Automatic Generation of Process Models for Fed-Batch...
Imagen del vendedor
Automatic Generation of Process Models for Fed-Batch Fermentations Based on the Detection of Biological Phenomena
Impresión bajo demandaLibrería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Alemania
Calificación del vendedor: 5 de 5 estrellas
Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Using dynamic models to describe biotechnological processes leads to a better understanding of the complex process dynamics and helps to find optimal conditions that improve the process significantly. However, the development of adequate mathematical models is generally difficult, tedious, time-consuming, and requires extensive prior experimentation.This work presents an algorithm that automatically proposes process models from an automated processing and analysis of data from (fed-)batch experiments. For this purpose, the algorithm first uses different data smoothing and interpolation techniques to account for a typically noisy and poorly time-resolved data set. Then, the measurements are numerically compensated for the influence of feeding and sampling. To reveal the qualitative behavior of the measurements, a method is used that divides the compensated curves into several episodes in a probabilistic framework.Based on this qualitative description, crucial information about the underlying reaction network can be obtained. For this, different biological phenomena describing the relation between several measured variables are defined. Rules to (dis-)prove these phenomena are applied to the data. The detected biological phenomena and the used measured variables then lead to an automated proposal of several model structures with different degrees of complexity.Furthermore, a procedure to detect model deficiencies is drafted. The phenomena detection is applied to simulations of a model and compared to the measurement-inherent phenomena. This approach is initially tested on simple case studies.The presented algorithm is applied to fed-batch experiments of three different organisms. Structured models are generated, identified, and validated. The results show that the models still need to be improved, but, in many cases, are able to describe the dynamics satisfactorily. Thus, the presented approach helps to speed up the modeling process significantly. 184 pp. Englisch. Nº de ref. del artículo: 9783737529570
Comprar nuevo
EUR 19,90
Envío por EUR 23,00
Se envía de Alemania a Estados Unidos de America
Se envía de Alemania a Estados Unidos de America
Cantidad disponible: 2 disponibles
Imagen de archivo
Automatic Generation of Process Models for Fed-Batch Fermentations Based on the Detection of Biological Phenomena
Librería: Revaluation Books, Exeter, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Paperback. Condición: Brand New. 184 pages. 8.27x5.83x0.42 inches. In Stock. Nº de ref. del artículo: 3737529574
Comprar nuevo
EUR 39,57
Envío por EUR 11,47
Se envía de Reino Unido a Estados Unidos de America
Se envía de Reino Unido a Estados Unidos de America
Cantidad disponible: 1 disponibles
Imagen del vendedor
Automatic Generation of Process Models for Fed-Batch Fermentations Based on the Detection of Biological Phenomena : Dissertationsschrift
Librería: AHA-BUCH GmbH, Einbeck, Alemania
Calificación del vendedor: 5 de 5 estrellas
Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Using dynamic models to describe biotechnological processes leads to a better understanding of the complex process dynamics and helps to find optimal conditions that improve the process significantly. However, the development of adequate mathematical models is generally difficult, tedious, time-consuming, and requires extensive prior experimentation.This work presents an algorithm that automatically proposes process models from an automated processing and analysis of data from (fed-)batch experiments. For this purpose, the algorithm first uses different data smoothing and interpolation techniques to account for a typically noisy and poorly time-resolved data set. Then, the measurements are numerically compensated for the influence of feeding and sampling. To reveal the qualitative behavior of the measurements, a method is used that divides the compensated curves into several episodes in a probabilistic framework.Based on this qualitative description, crucial information about the underlying reaction network can be obtained. For this, different biological phenomena describing the relation between several measured variables are defined. Rules to (dis-)prove these phenomena are applied to the data. The detected biological phenomena and the used measured variables then lead to an automated proposal of several model structures with different degrees of complexity.Furthermore, a procedure to detect model deficiencies is drafted. The phenomena detection is applied to simulations of a model and compared to the measurement-inherent phenomena. This approach is initially tested on simple case studies.The presented algorithm is applied to fed-batch experiments of three different organisms. Structured models are generated, identified, and validated. The results show that the models still need to be improved, but, in many cases, are able to describe the dynamics satisfactorily. Thus, the presented approach helps to speed up the modeling process significantly. Nº de ref. del artículo: 9783737529570
Comprar nuevo
EUR 19,90
Envío por EUR 61,22
Se envía de Alemania a Estados Unidos de America
Se envía de Alemania a Estados Unidos de America
Cantidad disponible: 2 disponibles
Imagen del vendedor
Automatic Generation of Process Models for Fed-Batch Fermentations Based on the Detection of Biological Phenomena | Dissertationsschrift
Librería: preigu, Osnabrück, Alemania
Calificación del vendedor: 5 de 5 estrellas
Taschenbuch. Condición: Neu. Automatic Generation of Process Models for Fed-Batch Fermentations Based on the Detection of Biological Phenomena | Dissertationsschrift | Sebastian Herold | Taschenbuch | 184 S. | Englisch | 2015 | epubli | EAN 9783737529570 | Verantwortliche Person für die EU: Neopubli GmbH, Sebastian Stude, Köpenicker Str. 154a, 10997 Berlin, produktsicherheit[at]epubli[dot]com | Anbieter: preigu. Nº de ref. del artículo: 112093976
Comprar nuevo
EUR 19,90
Envío por EUR 70,00
Se envía de Alemania a Estados Unidos de America
Se envía de Alemania a Estados Unidos de America
Cantidad disponible: 5 disponibles