Protection & Regeneration Of Β-cells: Studies Using The Nod Mouse - Tapa blanda

Khoo, Cheen; Pozzilli, Paolo; Alison, Malcolm

 
9783659839191: Protection & Regeneration Of Β-cells: Studies Using The Nod Mouse
Tapa blanda
ISBN 10: 3659839191 ISBN 13: 9783659839191
Editorial: Scholars' Press, 2016

Sinopsis

Diabetes is a chronic disease affecting approximately 250 million people. To date, transplantation-based therapy is the therapy of choice; however, its success is hampered by the scarcity of transplantable human material. An alternative strategy is the promotion of regeneration in the pancreas. Endothelial progenitor cells (EPCs), a subpopulation of bone marrow (BM) cells, can contribute to tissue repair in various pathological conditions via the formation of new blood vessels. The role and regenerative potential of EPCs in diabetes using non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D) will be discussed. In addition to promoting endogenous β-cell regeneration using EPCs, a strategy to protect β-cell death via apoptosis, using a protease peptide XG-102 developed by Xigen was investigated. In conclusion, our results shown that both therapeutic strategies showed great promise in regenerating the damaged pancreas of NOD mice. While these strategies are still under further investigation, they offer encouragement in the quest for the treatment of early diabetes in the future.

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Reseña del editor

Diabetes is a chronic disease affecting approximately 250 million people. To date, transplantation-based therapy is the therapy of choice; however, its success is hampered by the scarcity of transplantable human material. An alternative strategy is the promotion of regeneration in the pancreas. Endothelial progenitor cells (EPCs), a subpopulation of bone marrow (BM) cells, can contribute to tissue repair in various pathological conditions via the formation of new blood vessels. The role and regenerative potential of EPCs in diabetes using non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D) will be discussed. In addition to promoting endogenous β-cell regeneration using EPCs, a strategy to protect β-cell death via apoptosis, using a protease peptide XG-102 developed by Xigen was investigated. In conclusion, our results shown that both therapeutic strategies showed great promise in regenerating the damaged pancreas of NOD mice. While these strategies are still under further investigation, they offer encouragement in the quest for the treatment of early diabetes in the future.

Biografía del autor

Cheen P Khoo, Ph.D. started her research career 12 years ago investigating the potential of embryonic and adult stem cells to treat Type 1 diabetes.She followed on to study the role of microRNAs to regulate blood vessel formation. Currently her focus is to design and develop therapeutic angiogenic products to treat various vascular diseases.

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Editorial
Scholars' Press
Año de publicación
2016
Idioma
Inglés
ISBN 10 
3659839191
ISBN 13 
9783659839191
Encuadernación
Tapa blanda
Número de páginas
208
Contacto del fabricante
no disponible
Persona responsable
no disponible