Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin: Gastro - retentive floating matrix tablets - Tapa blanda

Dudhipala, Narendar; Reddy, Sunil; Yamsani, Madhusudan Rao

 
9783659238147: Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin: Gastro - retentive floating matrix tablets
Tapa blanda
ISBN 10: 3659238147 ISBN 13: 9783659238147
Editorial: LAP LAMBERT Academic Publishing, 2012

Sinopsis

The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up.

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Reseña del editor

The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up.

Biografía del autor

Mr. Narendar Reddy Dudhipala, presently Research Scholar under the supervision of Prof. V. Kishan in the Department of Pharmaceutics at University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AndraPradesh, India. He completed His B.Pharm and M.Pharm from Kakatiya University. He received “Research Excellence awrad” in 63rd IPC.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2012
Idioma
Inglés
ISBN 10 
3659238147
ISBN 13 
9783659238147
Encuadernación
Tapa blanda
Número de páginas
64
Contacto del fabricante
no disponible
Persona responsable
no disponible