Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet: Development and Characterization of Compression Coated Colon Targeted Tablet of 5-Fluorouracil - Tapa blanda

Patel, Mukesh; Patel, Kanu; Patel, Natvarlal

 
9783659221941: Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet: Development and Characterization of Compression Coated Colon Targeted Tablet of 5-Fluorouracil
Tapa blanda
ISBN 10: 3659221945 ISBN 13: 9783659221941
Editorial: LAP LAMBERT Academic Publishing, 2012

Sinopsis

The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P<0.05). Results of Tukey test showed the relative contribution of each level of different factors for the response studied.

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Reseña del editor

The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P<0.05). Results of Tukey test showed the relative contribution of each level of different factors for the response studied.

Biografía del autor

DR. Mukesh R Patel did B.Pharm from N M University & M.Pharm From Rajiv Gandhi University and doctorate From H N G University, Gujarat, India.He started his carrier as a Lecturer and currently working as associate professor and HOD in Pharmaceutics at BMCPER, Modasa.He has Published number of Research Papers in National and International journals.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2012
Idioma
Inglés
ISBN 10 
3659221945
ISBN 13 
9783659221941
Encuadernación
Tapa blanda
Número de páginas
112
Contacto del fabricante
no disponible
Persona responsable
no disponible