Potential HIV Reverse Transcriptase Inhibitors: Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors - Tapa blanda

P. Patel, Komal; Patel, Jimish R.; Giridhar, Rajani

 
9783659184710: Potential HIV Reverse Transcriptase Inhibitors: Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors
Tapa blanda
ISBN 10: 3659184713 ISBN 13: 9783659184710
Editorial: LAP LAMBERT Academic Publishing, 2012

Sinopsis

The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.

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Reseña del editor

The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.

Biografía del autor

Ms. Komal Patel has obtained her Master of Pharmacy degree in Pharmaceutical Chemistry in 2010. She has published different international and National Research paper in synthetic Chemistry, Analytical Chemistry and Drug Design.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2012
Idioma
Inglés
ISBN 10 
3659184713
ISBN 13 
9783659184710
Encuadernación
Tapa blanda
Número de páginas
68
Contacto del fabricante
no disponible
Persona responsable
no disponible