Development and Evaluation of Proliposomes-Based Drug Delivery Systems: Proliposomes-Based Drug Delivery Systems - Tapa blanda

Gupta, Sandeep; Ahirwar, Dheeraj; Pandey, Aditya Nath

 
9783659160981: Development and Evaluation of Proliposomes-Based Drug Delivery Systems: Proliposomes-Based Drug Delivery Systems
Tapa blanda
ISBN 10: 3659160989 ISBN 13: 9783659160981
Editorial: LAP LAMBERT Academic Publishing, 2012

Sinopsis

The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.

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Reseña del editor

The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.

Biografía del autor

(M. Pharm, Phd)School of Pharmacy, Chouksey Engineering College.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2012
Idioma
Inglés
ISBN 10 
3659160989
ISBN 13 
9783659160981
Encuadernación
Tapa blanda
Número de páginas
64
Contacto del fabricante
no disponible
Persona responsable
no disponible