Artículos relacionados a Modelling Proteasome Dynamics in a Bayesian Framework...

Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters) - Tapa blanda

Libro 53 de 91: BestMasters

Stübler, Sabine

 
9783658201661: Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters)
Tapa blanda
ISBN 10: 3658201665 ISBN 13: 9783658201661
Editorial: Springer Spektrum, 2017

Sinopsis

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

"Sinopsis" puede pertenecer a otra edición de este libro.

Acerca del autor

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

De la contraportada

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

Contents
  • Structure and Function of the Proteasome
  • Approaches to Model Proteasome Dynamics
  • Comparison of the Dynamics of Proteasome Subtypes
  • Inhibitor Influence on the Catalytic Subunits 
  • Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model 
Target Groups
  • Lecturers and students of systems biology, immunology and cell biology
  • Practitioners from the fields of systems biology, immunology and cell biology
About the Author
Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Springer Spektrum
Año de publicación
2017
Idioma
Inglés
ISBN 10 
3658201665
ISBN 13 
9783658201661
Encuadernación
Tapa blanda
Número de páginas
112
Contacto del fabricante
no disponible
Persona responsable
no disponible