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Origin and Evolution of the Vertebrate Immune System: v.248 (Current Topics in Microbiology and Immunology) - Tapa dura

Libro 150 de 253: Current Topics in Microbiology and Immunology
 
9783540664147: Origin and Evolution of the Vertebrate Immune System: v.248 (Current Topics in Microbiology and Immunology)
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ISBN 10: 3540664149 ISBN 13: 9783540664147
Editorial: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2000

Sinopsis

The book presents the current knowledge, ideas and speculations about the origin of the adaptive immune system and its evolution. The accumulation of genetic, molecular and biological data across various classes of vertebrates and phyla within the animal kingdom has helped elucidate major elements of genetic conservation and specific variations on that theme. Several scenarios linking together genome evolution and the origin of receptors and the differentiation of lymphocyte lineage are now envisioned at a much more general and integrated level than before. The volume is a collection of chapters centered around the phylogeny of the immune system written by scientists. It presents a mix of subjects and new approaches in the form of reviews. The book delineates the current and controversial issues in this area.

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Reseña del editor

The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop­ ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte­ brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or­ igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo­ lecular contexts in which the mechanism was introduced.

Reseña del editor

The book presents the current knowledge, ideas and speculations about the origin of the adaptive immune system and its evolution. The accumulation of genetic, molecular and biological data across various classes of vertebrates and phyla within the animal kingdom has helped elucidate major elements of genetic conservation and specific variations on that theme. Several scenarios linking together genome evolution and the origin of receptors and the differentiation of lymphocyte lineage are now envisioned at a much more general and integrated level than before. The volume is a collection of chapters centered around the phylogeny of the immune system written by scientists. It presents a mix of subjects and new approaches in the form of reviews. The book delineates the current and controversial issues in this area.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Año de publicación
2000
Idioma
Inglés
ISBN 10 
3540664149
ISBN 13 
9783540664147
Encuadernación
Tapa dura
Número de páginas
335
Editor
Pasquier Louis Du, Litman Gary W., Du Pasquier L.
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
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