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Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk (Vol 1) (Handbook of Experimental Pharmacology) - Tapa dura

Libro 49 de 124: Handbook of Experimental Pharmacology
 
9783540612599: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk (Vol 1) (Handbook of Experimental Pharmacology)
Tapa dura
ISBN 10: 3540612599 ISBN 13: 9783540612599
Editorial: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1996

Sinopsis

This text, part of a two-volume set, reviews current assessment of how embryos accomplish the feat of biochemical processes that drive morphogenesis and which are thus at risk to disruption, and the mechanisms of action by which known human teratogens exert their unwanted effects.

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Reseña del editor

Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.

Reseña del editor

The prevention of birth defects in the human populations caused by exogenous chemicals is a goal of both primary care providers, drug developers, experimental teratologists, and risk assessors. This two-volume work provides a state-of- the-science assessment of how embryos accomplish the feat of morphogenesis at the molecular and cellular level, the key biochemical processes that drive morphogenesis and which are thus at risk to disruption, and the mechanisms of action by which known human teratogens exert their unwanted effects. These volumes provide the first comprehensive compilation of material focused on the understanding of the mechanism of action of chemicals which cause birth defects. It will prove a valuable reference work for clinicians, health councilors, teratologists, developmental biologists and risk assessors.

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Editorial
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Año de publicación
1996
Idioma
Inglés
ISBN 10 
3540612599
ISBN 13 
9783540612599
Encuadernación
Tapa dura
Número de páginas
638
Editor
Kavlock R.J., Daston G.P
Contacto del fabricante
no disponible
Persona responsable
no disponible