The Scid Mouse (The Current Topics in Microbiology and Immunology: Characterization and Potential Uses) - Tapa dura

Phillips, R.

 
9783540515128: The Scid Mouse (The Current Topics in Microbiology and Immunology: Characterization and Potential Uses)
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ISBN 10: 3540515127 ISBN 13: 9783540515128
Editorial: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1989

Reseña del editor

During routine genetic screening of several immunoglobulin heavy chain congenic mouse strains in 1980, one of us (MB) was surprised to find that several mice in the C.B-17IIcr strain, which was being maintained in a specific-pathogen-free facility of the Fox Chase Cancer Center (Philadelphia, PA), did not express serum immunoglobulin of the appropriate allotype. Fearing an error in the breeding of these mice, the sera of the suspect mice were screened for other allotypes. When these tests revealed a complete absence of serum immunoglobulin, it became apparent that a mutation had probably occurred in the C.B-17IIcr line. Further analysis revealed that a single breeding pair was respon­ sible for all of the immunoglobulin negative mice and that the defect showed recessive inheritance. Thus was the C.B-17/Icr scid or severe combined immune deficient (scid) mouse discovered. Although it has taken most animal facilities several years to breed scid mice of high quality for experimental purpose, it was clear by 1987 that many investigators were beginning to exploit the unique qualities of the scid mouse for studies in several areas.

Reseña del editor

This is the first book to focus on the use of the scid mouse in biomedical science which summarizes all of the current research. It provides an up-to-date, comprehensive, and critical appraisal of the strengths and weaknesses of this unusual mouse mutant as a model in various areas in basic and medical research.

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Editorial
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Año de publicación
1989
Idioma
Inglés
ISBN 10 
3540515127
ISBN 13 
9783540515128
Encuadernación
Tapa dura
Número de páginas
263
Editor
Phillips R., Et Al
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Alemania

Otras ediciones populares con el mismo título

9783642749759: The Scid Mouse: Characterization and Potential Uses

Edición Destacada

ISBN 10:  3642749755 ISBN 13:  9783642749759
Editorial: Springer, 2011
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