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Data Mining in Structural Biology: Signal Transduction and Beyond: v. 34 (Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements) - Tapa dura

 
9783540414940: Data Mining in Structural Biology: Signal Transduction and Beyond: v. 34 (Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements)
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ISBN 10: 3540414940 ISBN 13: 9783540414940
Editorial: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2001

Sinopsis

This work combines biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It describes how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed.

"Sinopsis" puede pertenecer a otra edición de este libro.

Reseña del editor

Structural biology is becoming a routine technique for structure de­ termination in pharmaceutical industries. The advances in molecular biology, crystal handling and data collection techniques, tunable syn­ chrotron radiation sources, and high-performance computing have all contributed to developments such as the production and expression of tailored protein domains, the use of the MAD (Multiple Anomalous Dispersion) method, and the collection of X-ray data from tiny crystals at cryogenic temperature. The number of protein structures deposited in the Protein Databank has increased tremendously over the last 3-4 years. Since 1997, more than 1,500 structures have been deposited each year, and during the first 7 months of this year, 1,500 protein structures were already deposited. The numerous initiatives in the field of "structural genomics" distributed all over the world have led to the development of techniques for high-throughput structure determina­ tion, thereby contributing to the increase in the determination of three­ dimensional protein structures. This structural information is being ex­ plored in various ways in the drug discovery process. It is not only used in structure-based drug design of new low-molecular-weight li­ gands, but also in the early stages of target validation and assessment. With the number of protein sequences without significant homology to well-known proteins increasing, the technique of structure-sequence compatibility (threading) is increasingly used to assign a function to a given protein fold.

Reseña del editor

This work combines biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It describes how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Año de publicación
2001
Idioma
Inglés
ISBN 10 
3540414940
ISBN 13 
9783540414940
Encuadernación
Tapa dura
Número de páginas
222
Editor
Schlichting Ilme, Egner Ursula
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
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