Sinopsis
Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant with significant pharmacological properties like adaptogenic, antioxidant, hypoglycemic and anti-stroke effects. Several of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates phytochemical and analytical studies on NMITLI118RT+ a candidate drug under the CSIR umbrella (derived from a new chemotype of W. somnifera). Here we report the development validation and applications of a simple, rapid and reliable isocratic HPLC method for quantification of Withanolide A in NMITLI118RT+ on a CN column utilizing gliclazide as an internal standard which could detect Withanolide A at about 3.8 min and gliclazide (internal standard) at about 4.8 min with a linearity range of 2-20 µg/mL. A second method here reports the development and validation of a simple isocratic method for simultaneous estimation of Withanolide A and Withanone (sesquiterpene lactone markers) established on a C-18; 3µ column which could detect Withanolide A and Withanone at retention times of about 20.7 min and 21.6 min respectively in the linearity range of 2-50 µg/mL for both.
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Reseña del editor
Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant with significant pharmacological properties like adaptogenic, antioxidant, hypoglycemic and anti-stroke effects. Several of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates phytochemical and analytical studies on NMITLI118RT+ a candidate drug under the CSIR umbrella (derived from a new chemotype of W. somnifera). Here we report the development validation and applications of a simple, rapid and reliable isocratic HPLC method for quantification of Withanolide A in NMITLI118RT+ on a CN column utilizing gliclazide as an internal standard which could detect Withanolide A at about 3.8 min and gliclazide (internal standard) at about 4.8 min with a linearity range of 2-20 µg/mL. A second method here reports the development and validation of a simple isocratic method for simultaneous estimation of Withanolide A and Withanone (sesquiterpene lactone markers) established on a C-18; 3µ column which could detect Withanolide A and Withanone at retention times of about 20.7 min and 21.6 min respectively in the linearity range of 2-50 µg/mL for both.
Biografía del autor
The author has pursued her master’s and doctoral studies in Pharmacognosy. Her work has extensively dealt with standardization, analytical methodologies and drug delivery systems dealing with herbal candidates and medicinal plants. She is a recipient of several prestigious fellowships and grants and has several research papers, reviews and chapters
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Analytical studies on a standardized extract of Withania somnifera L.
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LAP LAMBERT Academic Publishing Jun 2017, 2017
ISBN 10: 3330343206
ISBN 13: 9783330343207
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant with significant pharmacological properties like adaptogenic, antioxidant, hypoglycemic and anti-stroke effects. Several of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates phytochemical and analytical studies on NMITLI118RT+ a candidate drug under the CSIR umbrella (derived from a new chemotype of W. somnifera). Here we report the development validation and applications of a simple, rapid and reliable isocratic HPLC method for quantification of Withanolide A in NMITLI118RT+ on a CN column utilizing gliclazide as an internal standard which could detect Withanolide A at about 3.8 min and gliclazide (internal standard) at about 4.8 min with a linearity range of 2-20 µg/mL. A second method here reports the development and validation of a simple isocratic method for simultaneous estimation of Withanolide A and Withanone (sesquiterpene lactone markers) established on a C-18; 3µ column which could detect Withanolide A and Withanone at retention times of about 20.7 min and 21.6 min respectively in the linearity range of 2-50 µg/mL for both. 52 pp. Englisch. Nº de ref. del artículo: 9783330343207
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Analytical studies on a standardized extract of Withania somnifera L.
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LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330343206
ISBN 13: 9783330343207
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Analytical studies on a standardized extract of Withania somnifera L.
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LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330343206
ISBN 13: 9783330343207
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Analytical studies on a standardized extract of Withania somnifera L.
Publicado por
LAP LAMBERT Academic Publishing Jun 2017, 2017
ISBN 10: 3330343206
ISBN 13: 9783330343207
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Taschenbuch. Condición: Neu. Neuware -Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant with significant pharmacological properties like adaptogenic, antioxidant, hypoglycemic and anti-stroke effects. Several of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates phytochemical and analytical studies on NMITLI118RT+ a candidate drug under the CSIR umbrella (derived from a new chemotype of W. somnifera). Here we report the development validation and applications of a simple, rapid and reliable isocratic HPLC method for quantification of Withanolide A in NMITLI118RT+ on a CN column utilizing gliclazide as an internal standard which could detect Withanolide A at about 3.8 min and gliclazide (internal standard) at about 4.8 min with a linearity range of 2-20 µg/mL. A second method here reports the development and validation of a simple isocratic method for simultaneous estimation of Withanolide A and Withanone (sesquiterpene lactone markers) established on a C-18; 3µ column which could detect Withanolide A and Withanone at retention times of about 20.7 min and 21.6 min respectively in the linearity range of 2-50 µg/mL for both.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Englisch. Nº de ref. del artículo: 9783330343207
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Analytical studies on a standardized extract of Withania somnifera L.
Publicado por
LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330343206
ISBN 13: 9783330343207
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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Withania somnifera Dunal (Ashwagandha) is an Indian medicinal plant with significant pharmacological properties like adaptogenic, antioxidant, hypoglycemic and anti-stroke effects. Several of its chemotypes includes NMITLI-101, NMITLI-118, NMITLI-128. The present work elaborates phytochemical and analytical studies on NMITLI118RT+ a candidate drug under the CSIR umbrella (derived from a new chemotype of W. somnifera). Here we report the development validation and applications of a simple, rapid and reliable isocratic HPLC method for quantification of Withanolide A in NMITLI118RT+ on a CN column utilizing gliclazide as an internal standard which could detect Withanolide A at about 3.8 min and gliclazide (internal standard) at about 4.8 min with a linearity range of 2-20 µg/mL. A second method here reports the development and validation of a simple isocratic method for simultaneous estimation of Withanolide A and Withanone (sesquiterpene lactone markers) established on a C-18; 3µ column which could detect Withanolide A and Withanone at retention times of about 20.7 min and 21.6 min respectively in the linearity range of 2-50 µg/mL for both. Nº de ref. del artículo: 9783330343207
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Analytical studies on a standardized extract of Withania somnifera L.
Publicado por
LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330343206
ISBN 13: 9783330343207
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Taschenbuch. Condición: Neu. Analytical studies on a standardized extract of Withania somnifera L. | Hafsa Ahmad (u. a.) | Taschenbuch | 52 S. | Englisch | 2017 | LAP LAMBERT Academic Publishing | EAN 9783330343207 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Nº de ref. del artículo: 109487128
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