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Libro 44 de 50: Progress in Inflammation Research
 
9783319833088: The Blood Brain Barrier and Inflammation (Progress in Inflammation Research)
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ISBN 10: 3319833081 ISBN 13: 9783319833088
Editorial: Springer, 2018

Sinopsis

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

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Acerca del autor

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.

De la contraportada

Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.

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Editorial
Springer
Año de publicación
2018
Idioma
Inglés
ISBN 10 
3319833081
ISBN 13 
9783319833088
Encuadernación
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Número de páginas
292
Editor
Lyck Ruth, Enzmann Gaby
Contacto del fabricante
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Otras ediciones populares con el mismo título

9783319455129: The Blood Brain Barrier and Inflammation (Progress in Inflammation Research)

Edición Destacada

ISBN 10:  3319455125 ISBN 13:  9783319455129
Editorial: Springer-Verlag GmbH, 2017
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