The Functional Nucleus - Tapa blanda

Graham Dellaire

 
9783319817682: The Functional Nucleus

Sinopsis

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

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Acerca del autor

David P. Bazett-JonesThe Hospital for Sick Children, Toronto, ON, Canada 
                Graham DellaireDalhousie University, Halifax, NS, Canada

De la contraportada

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

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Otras ediciones populares con el mismo título

9783319388809: The Functional Nucleus

Edición Destacada

ISBN 10:  3319388800 ISBN 13:  9783319388809
Editorial: Springer, 2016
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