Assembly and function of the precursor B-cell receptor.- Receptor Dissociation and B cell activation.- Molecular mechanisms of B cell antigen gathering and endocytosis.- BTK signaling in B cell differentiation and autoimmunity.- The memory function of the B cell antigen receptor.- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL).- Role of Calcium Signaling in B Cell Activation and Biolog.- Roles of the NF-kappaB pathway in B-lymphocyte biology.- MAP kinase cascades in antigen receptor signaling and physiology.
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Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca2+ mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton's Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases. 244 pp. Englisch. Nº de ref. del artículo: 9783319798998
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Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca2+ mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton's Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, whilealso paving the way for eventually combating thesediseases. Nº de ref. del artículo: 9783319798998
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Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca2+ mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton¿s Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, whilealso paving the way for eventually combating thesediseases.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch. Nº de ref. del artículo: 9783319798998
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