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Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones (Springer Theses) - Tapa blanda

Doran, Robert

 
9783319370347: Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones (Springer Theses)
Tapa blanda
ISBN 10: 3319370340 ISBN 13: 9783319370347
Editorial: Springer, 2016

Sinopsis

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

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Acerca del autor

Robert, from Co. Wicklow, Ireland, graduated from University College Dublin in 2010 with a 1st class Honours BSc in Chemistry completing his final year project under the supervision of Professor Pat Guiry in the synthesis of aromatic Lipoxin analogues. He was awarded an Embark Postgraduate Scholarship from the Irish Research Council (IRC) in to undertake PhD studies with Professor Pat Guiry on the total synthesis of lactone-containing natural products and catalytic asymmetric synthesis of α-aryl ketones. Following his PhD he moved to Imperial College London as a post-doctoral research associate with Dr James A. Bull working on the synthesis and functionalisation of oxetanes.

De la contraportada

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.

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Editorial
Springer
Año de publicación
2016
Idioma
Inglés
ISBN 10 
3319370340
ISBN 13 
9783319370347
Encuadernación
Tapa blanda
Número de páginas
202
Contacto del fabricante
ProductSafety@springernature.com
ProductSafety@springernature.com

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