Mechanisms of Secondary Brain Damage: Current State - Tapa dura
Libro 34 de 91: Acta Neurochirurgica Supplement
Sinopsis
The volume presents an interdisciplinary discussion on the current knowledge of mechanisms of secondary brain damage evolving from cerebral trauma or ischemia. Specific topics focus on functional analysis of the brain by NMR-spectroscopy or PET-scanning, as well as on quantitative histomorphological assessment of primary versus secondary lesions in neuro-traumatology. Other chapters are concerned with the acid-base regulation in cerebral ischemia, and the current understanding of clinically relevant mediator compounds enhancing tissue damage in trauma or ischemia, in particular focusing on the amino acid glutamate. Valuable information is gleaned from recent investigations on the recovery potential of the brain from ischemia in men, or the most modern treatment modalities of cerebral resuscitation after cardiac arrest, combining research from cardiopulmonary bypass, haemodilution and hypothermia. Further highlights of the text include a discussion of the present state of prehospital emergency care, including logistics, training of personnel and availability of specific trauma centres, and evaluations of the clinical management of intracranial hypertension and brain tissue acidosis in severe head injury.
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Reseña del editor
Great progress has been made in the understanding and prevention of secondary brain damage from acute cerebral disorders, such as trauma and ischemia. Advances may be concerned in particular with better organization and logistics of preclinical emergency care, including rapid arrival of well-trained medical staff on the scene of an accident and of transportation to a competent hospital. Nevertheless, it is a safe assumption that development of secondary brain damage from both intra- and extracranial causes still represents a major factor for the final outcome in severe head injury. Thus, exchanges of experiences and information between various disciplines involved with this important clinical problem - trauma still assumes the number one position as a cause of morbidity and mortality up to an age of 45 years - may provide a basis for in-depth analysis of remaining problems as well as of methods of their solution. This exactly is the purpose of the present publication on concepts and findings pertinent for the general subject of secondary brain damage from various experimental as well as clinical viewpoints. An internationally high-ranking group of experts has been contributing to this collection of reviews on cerebral trauma and ischemia and its adverse sequelae, including cerebral exploration by most modern technologies, such as NMR spectroscopy or PET scanning, among others.
Reseña del editor
The volume presents an interdisciplinary discussion on the current knowledge of mechanisms of secondary brain damage evolving from cerebral trauma or ischemia. Specific topics focus on functional analysis of the brain by NMR-spectroscopy or PET-scanning, as well as on quantitative histomorphological assessment of primary versus secondary lesions in neuro-traumatology. Other chapters are concerned with the acid-base regulation in cerebral ischemia, and the current understanding of clinically relevant mediator compounds enhancing tissue damage in trauma or ischemia, in particular focusing on the amino acid glutamate. Valuable information is gleaned from recent investigations on the recovery potential of the brain from ischemia in men, or the most modern treatment modalities of cerebral resuscitation after cardiac arrest, combining research from cardiopulmonary bypass, haemodilution and hypothermia. Further highlights of the text include a discussion of the present state of prehospital emergency care, including logistics, training of personnel and availability of specific trauma centres, and evaluations of the clinical management of intracranial hypertension and brain tissue acidosis in severe head injury.
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