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Matrix Metalloproteinases in Health and Disease - Tapa dura

 
9783039430529: Matrix Metalloproteinases in Health and Disease
Tapa dura
ISBN 10: 3039430521 ISBN 13: 9783039430529
Editorial: MDPI AG, 2020

Sinopsis

Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual’s disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems.

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Editorial
MDPI AG
Año de publicación
2020
Idioma
Inglés
ISBN 10 
3039430521
ISBN 13 
9783039430529
Encuadernación
Tapa dura
Número de páginas
196
Editor
Serra Raffaele
Contacto del fabricante
no disponible
Persona responsable
no disponible