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G-quadruplex and Microorganisms - Tapa blanda

 
9783039212439: G-quadruplex and Microorganisms
Tapa blanda
ISBN 10: 3039212435 ISBN 13: 9783039212439
Editorial: MDPI AG, 2019

Sinopsis

G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.

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Editorial
MDPI AG
Año de publicación
2019
Idioma
Inglés
ISBN 10 
3039212435
ISBN 13 
9783039212439
Encuadernación
Tapa blanda
Número de páginas
208
Editor
Richter Sara N.
Contacto del fabricante
no disponible
Persona responsable
no disponible