Algorithms and Methods in Structural Bioinformatics (Computational Biology) - Tapa dura

 
9783031059131: Algorithms and Methods in Structural Bioinformatics (Computational Biology)
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ISBN 10: 3031059131 ISBN 13: 9783031059131
Editorial: Springer, 2022

Sinopsis

The three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved.


In this book we focus on a number of topics in Structural Bioinformatics: Cryo-EM structural detection, protein conformational exploration, elucidation of molecular binding surface using geometry, the effect of mutations, insertions and deletions on protein structural stability, and protein-ligand binding.

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Acerca del autor

​Nurit Haspel has been a member of the Department of Computer Science at the University of Massachusetts, Boston since 2009. She received her Ph.D. from Tel Aviv University in 2007. Her research lies in the areas of computational structural biology and structural bioinformatics. Her goal is to better understand the structure and flexibility of proteins, to model conformational changes in proteins, and to model protein-protein interactions. In her research, she focuses on both the development of novel algorithms and the application of state-of-the-art existing methodologies to various problems in molecular biology and biochemistry.
Filip Jagodzinski joined the faculty of Western Washington University in 2015. He earned his Ph.D. from the University of Massachusetts, Amherst in 2012, and his MS from Villanova and BS from Columbia University. With his undergraduate and graduate students, and in coordination with Machine Learning and biology and chemistrycollaborators, Filip develops computational recipes for predicting the structural properties of disease-causing protein mutants and inferring the effects of indels. Their tools are often disseminated via web servers or as open-source software.Kevin Molloy joined the faculty at James Madison University in 2018.  He earned his Ph.D. from George Mason University in 2015, his MS from George Mason in 2011, and his BS from George Mason in 1998.   His research focuses on studying the flexibility of protein systems and the role this flexibility plays in their function, specifically in antimicrobial peptides.  He is also developing algorithms to characterize the structural rearrangements that proteins undertake to fluctuate their functional roles and how amino acid sequence mutations impact these transitions.

De la contraportada

The three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved.
In this book we focus on a number of topics in Structural Bioinformatics: Cryo-EM structural detection, protein conformational exploration, elucidation of molecular binding surface using geometry, the effect of mutations, insertions and deletions on protein structural stability, and protein-ligand binding.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Springer
Año de publicación
2022
Idioma
Inglés
ISBN 10 
3031059131
ISBN 13 
9783031059131
Encuadernación
Tapa dura
Número de edición
1
Número de páginas
126
Editor
Haspel Nurit, Jagodzinski Filip, Molloy Kevin
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
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Friedrich-Karl-Str. 9
Hamburg
Alemania

Otras ediciones populares con el mismo título

9783031059162: Algorithms and Methods in Structural Bioinformatics (Computational Biology)

Edición Destacada

ISBN 10:  3031059166 ISBN 13:  9783031059162
Editorial: Springer, 2023
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