Protein Targeting and Translocation: 12 (Research Monograph) - Tapa dura

Reseña del editor

Within a eukaryotic organism up to 95 per cent weight for weight of the cell's membranes are used in the formation of intracellular structures such as the nucleus, endoplasmic reticulum ER, golgi, mitochondria, chloroplasts and microbodies, (peroxisomes/glyoxisomes). To allow each membrane bound compartment to carry out its role there is considerable protein traffic between proteins and they must be able to pass across these semi-permeable barriers and in the case of membrane proteins insert into the bilayer. Furthermore the cell must have a means of maintaining proteins at their final functional location against the bulk flow of protein for example in the ER and golgi. The mechanism by which large proteins are able to undergo subcellular targeting and then cross a hydrophobic bilayer has been one that has puzzled scientists for a number of years and a question that has been investigated by a wide range of techniques from biophysics to molecular biology. By bringing together experts in the field this book aims to go some way ahead to answering these questions.