Kinase Inhibitors: Methods and Protocols: 795 (Methods in Molecular Biology, 795) - Tapa dura

Sinopsis

1. Targeting Cancer with Small Molecular Weight Kinase Inhibitors Doriano Fabbro, Sandra W. Cowan-Jacob, Henrik Möbitz, and Georg Martiny-Baron 2. Small Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for their Evaluation Matthias Gaestel and Alexey Kotlyarov 3. Measuring the Activity of Leucine Rich Repeat Kinase 2 (LRRK2) - A Kinase Involved in Parkinson’s Disease Byoung Dae Lee, Xiaojie Li, Ted M. Dawson, and Valina L. Dawson 4. Measuring PI3K Lipid Kinase Activity Elisa Ciraolo, Alessia Perino, and Emilio Hirsch 5. A Fluorescence Polarization Assay for the Discovery of Inhibitors of the Polo-box Domain of Polo-like Kinase 1 Wolfgang Reindl, Klaus Strebhardt, and Thorsten Berg 6. Assessment of Hepatotoxicity Potential of Drug Candidate Molecules Including Kinase Inhibitors by Hepatocyte Imaging Assay Technology and Bile Flux Imaging Assay Technology Jinghai J. Xu, Margaret C. Dunn, Arthur R. Smith, and Eric S. Tien 7. Kinase Inhibitor Selectivity Profiling using Differential Scanning Fluorimetry Oleg Fedorov, Frank H. Niesen, and Stefan Knapp 8. Chemoproteomic Characterization of Protein Kinase Inhibitors using Immobilized ATP James S. Duncan, Timothy A.J. Haystead, and David W. Litchfield 9. Proteome-wide identification of staurosporine-binding kinases using Capture Compound Mass Spectrometry Jenny J. Fischer, Olivia Y. Graebner neé Baessler, and Mathias Dreger 10. Affinity Purification of Proteins Binding to Kinase Inhibitors Immobilised on Self Assembling Monolayers Marcus Bantscheff, Scott Hobson, and Bernhard Kuster 11. Kinase Inhibitor Profiling using Chemoproteomics Markus Schirle, Eugene C. Petrella, Scott M. Brittain, David Schwalb, Edmund Harrington, Ivan Cornella-Taracido, and John A. Tallarico 12. Covalent Crosslinking of Kinases with Their Corresponding Peptide Substrates Alexander V. Statsuk and Kevan M. Shokat 13. Receptor Tyrosine Kinase Inhibitor Profiling using Bead-based Multiplex Sandwich Immunoassays Oliver Pötz, Nicole Schneiderhan-Marra, Tanja Henzler, Thomas Herget, and Thomas O. Joos 14. Monitoring Phosphoproteomic Response To Targeted Kinase Inhibitors Using Reverse-Phase Protein Microarrays Gabriela Lavezzari and Mark R. Lackner 15. Measuring Phosphorylation Specific Changes in Response to Kinase Inhibitors in Mammalian Cells Using Quantitative Proteomics Nurhan Özlü , Marc Kirchner, and Judith Jebanathirajah Steen 16. Investigation of Acquired Resistance to EGFR-Targeted Therapies in Lung Cancer Using cDNA Microarrays Kian Kani, Rafaella Sordella, and Parag Mallick

"Sinopsis" puede pertenecer a otra edición de este libro.