From the reviews:
"‘Gene Function Analysis’ is volume 408 of the ‘Methods in Molecular Biology’ series. The aim of the book is to provide both in silico and laboratory methods for the functional analysis of the large amount of gene expression data generated from high throughput technologies such as microarrays. ... This book would certainly be a useful addition to a laboratory interested in assessing gene function through both bioinformatic and ‘wet’ approaches. Definitely one for the more (toxico)genomically challenged amongst us." (James Sidaway, British Toxicology Society Newsletter, Summer, 2008)
With the advent of high-throughput technologies following completion of the human genome project and similar projects, the number of genes of interest has expanded and the traditional methods for gene function analysis cannot achieve the throughput necessary for large-scale exploration. This book brings together a number of recently developed techniques for looking at gene function, including computational, biochemical and biological methods and protocols.
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Descripción Soft Cover. Condición: new. Nº de ref. del artículo: 9781617377488
Descripción Condición: New. Nº de ref. del artículo: ABLIING23Mar2811580148551
Descripción Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With the advent of high-throughput technologies following completion of the human genome project and similar projects, the number of genes of interest has expanded and the traditional methods for gene function analysis cannot achieve the throughput necessary for large-scale exploration. This book brings together a number of recently developed techniques for looking at gene function, including computational, biochemical and biological methods and protocols. 337 pp. Englisch. Nº de ref. del artículo: 9781617377488
Descripción Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Brings together a number of techniques, both computational and biological, that have developed recently for looking at gene functionContains Notes sections with troubleshooting guidesEasy-to-follow laboratory methods and protocols. Nº de ref. del artículo: 458521605
Descripción Condición: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Nº de ref. del artículo: ria9781617377488_lsuk
Descripción Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume of Methods in Molecular Biology focuses on techniques to determine the function of a gene. Traditionally, the function of a gene was determined following cloning, which provided its DNA sequence and an ab- ity to modify this sequence. Experiments were performed that looked for p- notypic changes in a cell line or model organism following modifications to the sequence, knocking out of the gene, or enhancing expression of the gene. In the 1990's, the growing sequence databases and the BLAST algorithm provided additional power by allowing identification of genes with known function that had similar sequences and potentially similar molecular mechanisms. On the experimental side, methods, such as two-hybrid screening that could directly determine the partners of specific proteins and even the domains of interaction, came into widespread use. With the advent of high-throughput technologies following completion of the human genome project and similar projects in model organisms, the n- ber of genes of interest has expanded and the traditional methods for gene fu- tion analysis cannot achieve the throughput necessary for large-scale exploration. Although computational tools such as BLAST remain a good point of departure, it is often the case that a gene that appears interesting in a hi- throughput experiment shows no obvious similarity to a gene of known fu- tion. In addition, when BLAST does find a similar gene, the process has often only begun. Nº de ref. del artículo: 9781617377488