Lectin Methods and Protocols: 9 (Methods in Molecular Medicine) - Tapa blanda

 
9781617370243: Lectin Methods and Protocols: 9 (Methods in Molecular Medicine)
Tapa blanda
ISBN 10: 161737024X ISBN 13: 9781617370243
Editorial: Humana, 2010

Sinopsis

Lectins have in the past been regarded by many scientists as curious proteins of uncertain structure and specificity that bind to carbohydrates of dubious significance themselves. All this is rapidly changing. The functional importance of glycosylation in cell-cell and cell-pathogen interactions, as well as intracellular events, has been recognized by the explosion of the science of glycobiology. This has been paralleled by the realization that lectins, once they have been well characterized, can be extremely useful tools for exam- ing structural changes in glycosylation and their functional consequences for human pathophysiology. Different lectins vary considerably in their degree of specificity. Some, such as wheatgerm agglutinin, have fairly broad specificity (for glucosamine or sialic acid), whereas others, such as Maackia amurensis, are specific not only for a single carbohydrate, but also for its linkage (2-3 linked sialic acid). Lectins with relatively broad specificity may be very useful as an adjunct to isolation or quantification of soluble glycoproteins, whereas lectins of known, and precise, specificity will be more useful for characterization of carbo- drate structure. We have included an appendix in Lectin Methods and Pro- cols that provides the known specificities of all lectins cited in the text.

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De la contraportada

Lectin Methods and Protocols brings together a comprehensive collection of optimized methods for using lectins in biomedical research. The techniques-fine-tuned by the researchers who developed them-apply lectins to the analysis of carbohydrates, to the isolation and quantification of glycoproteins, and to living cells. Also included are step-by-step methods for the separation of human bone marrow cells for clinical use, for the assessment of the biological effects of plant lectins, and for the use of light and electron microscopy in analyzing carbohydrate structures. Taken together, the methods detailed here offer extremely useful tools for examining structural changes in glycosylation and their functional consequences for human pathophysiology

Lectin Methods and Protocols provides invaluable, easily reproducible techniques suitable for application to a wide range of important biomedical problems. The book will immediately become the standard practical resource and guide to lectin techniques for today's biomedical researchers.

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Editorial
Humana
Año de publicación
2010
Idioma
Inglés
ISBN 10 
161737024X
ISBN 13 
9781617370243
Encuadernación
Tapa blanda
Número de páginas
636
Editor
Rhodes Jonathan M., Milton Jeremy D.
Contacto del fabricante
no disponible
Persona responsable
no disponible

Otras ediciones populares con el mismo título

9780896033962: Lectin Methods and Protocols: 9 (Methods in Molecular Medicine, 9)

Edición Destacada

ISBN 10:  0896033961 ISBN 13:  9780896033962
Editorial: Humana Press, 1997
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