The Immune System and the Developing Brain (Colloquium Series on the Developing Brain) - Tapa blanda

Schwarz, Jaclyn M.; Bilbo, Staci D.

 
9781615043514: The Immune System and the Developing Brain (Colloquium Series on the Developing Brain)
Tapa blanda
ISBN 10: 1615043519 ISBN 13: 9781615043514
Editorial: Morgan & Claypool Life Sciences, 2011

Sinopsis

The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct or significantly alter the developmental trajectory of cells, neural circuits, and associated behavioral outcomes for the life of the individual. Contrary to initial dogma that the brain is one of the few organs within the body that is immune-privileged, evidence indicates that the immune system has a critical role in brain function during development as well as during sickness and health in adulthood. Microglia are the primary immune cells within the brain, and they are in constant communication with the peripheral immune system and surrounding cell types within the brain. We describe the important role of the immune system, including microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Growing evidence indicates that there is a strong link between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. Thus, understanding the role of the immune system and immune activation during the critical period of brain development is a necessary step toward understanding the potential origins of these devastating disorders.

Table of Contents: Introduction / The Immune Response / Brain-Immune Communication / Microglia Are Immune Cells of the Brain / The Functional Role of Microglia and Immune Molecules in Neurodevelopment / Early-Life Programming of Brain and Behavior: A Critical Role for the Immune System / Commonly Used Models of Early Life Immune Activation in the Rodent / Early Life Immune Activation and Cognitive Impairment in Adulthood / Mechanisms Underlying the Enduring Changes in Neuroimmune Function Caused by Early Life Infection / Toll-Like Receptors and Immune Activation During Early Brain Development / Environmental Triggers of TLR Activation: Long-Term Programming of Brain and Behavior / Future Directions to Understanding Immune Function and Brain Development / References

"Sinopsis" puede pertenecer a otra edición de este libro.

Reseña del editor

The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct or significantly alter the developmental trajectory of cells, neural circuits, and associated behavioral outcomes for the life of the individual. Contrary to initial dogma that the brain is one of the few organs within the body that is immune-privileged, evidence indicates that the immune system has a critical role in brain function during development as well as during sickness and health in adulthood. Microglia are the primary immune cells within the brain, and they are in constant communication with the peripheral immune system and surrounding cell types within the brain. We describe the important role of the immune system, including microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Growing evidence indicates that there is a strong link between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. Thus, understanding the role of the immune system and immune activation during the critical period of brain development is a necessary step toward understanding the potential origins of these devastating disorders. Table of Contents: Introduction / The Immune Response / Brain-Immune Communication / Microglia Are Immune Cells of the Brain / The Functional Role of Microglia and Immune Molecules in Neurodevelopment / Early-Life Programming of Brain and Behavior: A Critical Role for the Immune System / Commonly Used Models of Early Life Immune Activation in the Rodent / Early Life Immune Activation and Cognitive Impairment in Adulthood / Mechanisms Underlying the Enduring Changes in Neuroimmune Function Caused by Early Life Infection / Toll-Like Receptors and Immune Activation During Early Brain Development / Environmental Triggers of TLR Activation: Long-Term Programming of Brain and Behavior / Future Directions to Understanding Immune Function and Brain Development / References

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Morgan & Claypool Life Sciences
Año de publicación
2011
Idioma
Inglés
ISBN 10 
1615043519
ISBN 13 
9781615043514
Encuadernación
Tapa blanda
Número de páginas
128
Contacto del fabricante
no disponible
Persona responsable
no disponible