[Scientific Issues in Quantitative Cancer Risk Assessment] (By: Suresh H. Moolgavkar) [published: April, 2013] - Tapa blanda

Sinopsis

The Clonogenic Cells of the Rat Mammary and Thyroid Glands: Their Biology, Frequency of Initiation, and Promotion/Progression to Cancer.- The Somatic Mutational Component of Human Carcinogenesis.- Two-Event Carcinogenesis: Roles of Oncogenes and Antioncogenes.- Genetic Alterations during Carcinogenesis in Rodents: Implications for Cancer Risk Assessment.- Multistage Hepatocarcinogenesis in the Rat as a Basis for Models of Risk Assessment of Carcinogenesis.- Cell Proliferation and Hepatocarcinogenesis.- Cell Growth Dynamics and DNA Alterations in Carcinogenesis.- Two Mutation Model for Carcinogenesis: Relative Roles of Somatic Mutations and Cell Proliferation in Determining Risk.- Cancer Dose-Response Models Incorporating Clonal Expansion.- Transformation and Growth of Lung Adenomas in Mice Exposed to Urethane.- Cancer Modeling with Intermittent Exposures.- Possible Role of Selective Gap Junctional Intercellular Communication in Multistage Carcinogenesis.- Interindividual Variation in Human Chemical Carcinogenesis: Implications for Risk Assessment.- Utilizing Biologically Based Models to Estimate Carcinogenic Risk.- Variability of Unit Risk Estimates under Different Statistical Models and between Different Epidemiological Data Sets.- Carcinogenic Drugs: A Model Data-base for Human Risk Quantification.- Afterword: Some Thoughts on What Was Learned and Some Science Policy Issues.

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