Sister Chromatid Exchanges: 25 Years of Experimental Research Part B Genetic Toxicology and Human Studies - Tapa blanda

Sinopsis

of Part B.- Sce and Genetic Toxicology.- Sister Chromatid Exchange Analysis in Cultured Peripheral Blood Leukocytes of the Coldwater Marine Fish, Pacific Staghorn Sculpin (Leptocottus armatus): A Feasible System for Assessing Genotoxic Marine Pollutants.- SCE Studies in the Chick Embryo and Neonate: Actions of Mutagens in a Developing System.- SCE Induction by Indirect Mutagens/Carcinogens in Metabolically Active Cultured Mammalian Cell Lines.- Erythrocyte-Mediated Metabolic Activation Detected by SCE.- The Effect of Erythrocytes and Hemoglobin on Sister Chromatid Exchange Induction in Cultured Human Lymphocytes Exposed to Aniline HC1.- Development of Rodent Peripheral Blood Lymphocyte Culture Systems to Detect Cytogenetic Damage In Vivo.- Accumulation of SCEs in Lymphocytes During Chronic Ingestion of a Mutagen.- Elimination of Cyclophosphamide-Induced SCE in Lymphocytes of Rats with Time Post-treatment.- Detection of SCE in Rodent Cells Using the Activated Charcoal Bromodeoxyuridine System.- Assessment of Sister Chromatid Exchange in Spermatogonia and Intestinal Epithelium in Chinese Hamsters.- Sister Chromatid Exchanges in Mammalian Meiotic Chromosomes.- Human Studies.- Removal and Persistence of SCE-Inducing Damage in Human Lymphocytes In Vitro.- Persistence of SCE-Inducing Lesions after GO Exposure of Human Lymphocytes to Differing Classes of DNA-Damaging Chemicals.- Proliferative Kinetics and Chemical-Induced Sister Chromatid Exchanges in Human Lymphocyte Cultures.- Importance of the Mitogen in Sister Chromatid Exchange Studies.- Serum-and Plasma-Dependent Variations of Benzo(a)pyrene-Induced Sister Chromatid Exchange in Human Lymphocytes.- Analysis of Sister Chromatid Exchanges in Bloom Syndrome by Use of Endomitotic and Three-Way Differentiation Procedures.- Complementation Studies in Murine/Human Hybrids Suggest Multiple Etiology for Increased Rate ot Sister Chromatid Exchange in Mammalian Cells.- Different Properties in Lymphoblastoid Cell Lines from Patients with Bloom Syndrome.- Study of Basal Cell Nevus Syndrome Fibroblasts after Treatment with DNA-Damaging Agents.- DNA Interstrand Cross-linking, Repair, and SCE Mechanisms in Human Cells in Special Reference to Fanconi''s Anemia.- Human Health Situation and Chromosome Alterations: Sister Chromatid Exchange Frequency in Lymphocytes from Passive Smokers and Patients with Hereditary Diseases.- Sensitivities of Peripheral Lymphocytes from Healthy Humans and Cancer Patients to Induction of Sister Chromatid Exchanges by Genotoxicants.- Value and Significance of SCE in Human Leukemia and Cancer.- SCE and Cell Cycle Studies in Leukemia.- Sister Chromatid Exchange in Phytohemagglutinin-Stimulated Lymphocytes of Nonfamilial Cutaneous Malignant Melanoma Patients.- SCE Induction by Cytostatics and Its Relation to Iatrogenic Leukemogenesis.- Sister Chromatid Exchange Frequency and Cell Cycle Kinetics in Cancer Patients Treated with Cytostatic Drugs.- Monitoring Patients on Long-Term Drug Therapy for Genotoxic Effects.- Practical Applications of the SCE Studies for Guiding and Improving Chemotherapy.- Genotoxicity of Antiamebic, Anthelmintic, and Antimycotic Drugs in Human Lymphocytes.- Sister Chromatid Exchange Induction by Cigarette Smoke.- The SCE Test as a Tool for Cytogenetic Monitoring of Human Exposure to Occupational and Environmental Mutagens.- Sister Chromatid Exchanges in Workers Exposed to Low Doses of Styrene.- The Effects of Hypolipidemic Peroxisome Proliferators on the Induction of SCEs.- Ethylene Oxide and Some Factors Affecting the Mutagen Sensitivity of SCE in Humans.- General Discussion.- The Relevance of Sister Chromatid Exchange Studies to Public Health: Prevention and Intervention. Introduction to a General Discussion on the Interpretation of Sister Chromatid Exchange Data.- Summary of General Discussion.- List of Participants.

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