Molecular and Cellular Aspects of the Drug Addictions - Tapa blanda

 
9781461388197: Molecular and Cellular Aspects of the Drug Addictions
Tapa blanda
ISBN 10: 1461388198 ISBN 13: 9781461388197
Editorial: Springer, 2011

Sinopsis

In 1970 I gave up the chairmanship of the Department of Pharmacology at Stanford University Schoel of Medicine to devote full time to basic and clinical research on problems of drug addiction. In 1971 I developed the method of radioligand binding that led to the important characterization of opioid receptors in several laboratories. The extraordinary specificity of these receptors for morphine and related opiates suggested the likelihood that there were naturally occurring morphine-like molecules in the brain and other tissues. The systematic search for these molecules culminated in 1979 in the discovery, by my group, ofthe dynorphin peptides-one of the three families of opioid peptides, the first of which (the enkephalin family) had been discovered in Aberdeen, Scotland, in 1975. I also became involved in clinical research on the pharmacologic treatment of heroin addicts, for which I established the first large methadone mainte­ nance treatment program in California. My basic and clinical research experience convinced me that an institution encompassing laboratory research, studies on normal human volunteers, and treatment research, under a single roof, could expedite progress in understanding the drug addictions. That concept was transformed into reality by the founding, in 1974, of the Addiction Research Foundation of Palo Alto, California. The funds for construction of a laboratory were provided by a generous grant from the Drug Abuse Council (a consortium of several foundations), the president of which was Thomas L. Bryant.

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Reseña del editor

In 1970 I gave up the chairmanship of the Department of Pharmacology at Stanford University Schoel of Medicine to devote full time to basic and clinical research on problems of drug addiction. In 1971 I developed the method of radioligand binding that led to the important characterization of opioid receptors in several laboratories. The extraordinary specificity of these receptors for morphine and related opiates suggested the likelihood that there were naturally occurring morphine-like molecules in the brain and other tissues. The systematic search for these molecules culminated in 1979 in the discovery, by my group, ofthe dynorphin peptides-one of the three families of opioid peptides, the first of which (the enkephalin family) had been discovered in Aberdeen, Scotland, in 1975. I also became involved in clinical research on the pharmacologic treatment of heroin addicts, for which I established the first large methadone mainte­ nance treatment program in California. My basic and clinical research experience convinced me that an institution encompassing laboratory research, studies on normal human volunteers, and treatment research, under a single roof, could expedite progress in understanding the drug addictions. That concept was transformed into reality by the founding, in 1974, of the Addiction Research Foundation of Palo Alto, California. The funds for construction of a laboratory were provided by a generous grant from the Drug Abuse Council (a consortium of several foundations), the president of which was Thomas L. Bryant.

Reseña del editor

This book focuses on present knowledge of the biologic - in contrast to the psychologic - aspects of drug addiction and addictive behavior. It brings forth new lines of research in a subject that traditionally has been regarded as the domain of psychology and sociology. The individual predisposition to use addictive drugs repeatedly, and thus become addicted, varies strikingly from person to person. This implies important biological or even genetic differences, perhaps related to differences in structure and function of the reward systems of the brain. These and other biological, chemical, and genetic aspects are explored.

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Editorial
Springer
Año de publicación
2011
Idioma
Inglés
ISBN 10 
1461388198
ISBN 13 
9781461388197
Encuadernación
Tapa blanda
Número de páginas
260
Editor
Goldstein Avram
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Alemania

Otras ediciones populares con el mismo título

9780387968278: Molecular and Cellular Aspects of the Drug Addictions

Edición Destacada

ISBN 10:  038796827X ISBN 13:  9780387968278
Editorial: Springer-Verlag New York Inc., 1989
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