Phenotypes and Genotypes: The Search for Influential Genes: 18 (Computational Biology) - Tapa blanda

Acerca del autor

Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria.

Dr. Małgorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wrocław University, Poland.

Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wrocław University of Technology, Poland.

De la contraportada

This timely text presents a comprehensive guide to geneticassociation, a new and rapidly expanding field that aims to elucidate how ourgenetic code (genotypes) influences the traits we possess (phenotypes). Thebook provides a detailed review of methods of gene mapping used in associationwith experimental crosses, as well as genome-wide association studies. Emphasisis placed on model selection procedures for analyzing data from large-scalegenome scans based on specifically designed modifications of the Bayesianinformation criterion.

Topics and features:

• Presents a thorough introduction to the theoreticalbackground to studies of genetic association (both genetic and statistical)
  
• Reviews the latest advances in the field, highlighting theadvantages and shortcomings of the currently most commonly used methods
  
• Illustrates the properties of methods for mappingquantitative trait loci using computer simulations and the analysis of realdata
  
• Discusses open challenges that remain to be solved in thefuture
  
• Includes an extensive statistical appendix as a referencefor those who are not totally familiar with the fundamentals of statistics

This important work is essential reading for researchers andgraduate students wishing to enter the field of statistical genetics and/orinterested in statistical issues related to the analysis of high-dimensionaldata. No prior background knowledge of genetics is required, although somebasic mathematical and computer science skills are assumed.

Dr. Florian Frommlet is a researcher in the Center forMedical Statistics, Informatics, and Intelligent Systems at the MedicalUniversity of Vienna, Austria. Dr. Malgorzata Bogdan is an Associate Professorin the Institute of Mathematics at Wroclaw University, Poland. Dr. David Ramseyis a Senior Lecturer in the Department of Operations Research at WroclawUniversity of Technology, Poland.