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An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Computational Biology Series) - Tapa blanda
Sinopsis
Written for students and researchers in systems biology, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological networks, highlighting simple, recurring circuit elements that make up the regulation of cells and tissues.
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Uri Alon is the Abisch-Frenkel professor of systems biology at the Weizmann Institute of Science; https://www.weizmann.ac.il/mcb/UriAlon/homepage
De la contraportada
Written for students and researchers in systems biology, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological networks, highlighting simple, recurring circuit elements that make up the regulation of cells and tissues.
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An Introduction to Systems Biology: Design Principles of Biological Circuits
Publicado por
CRC Press & Chapman and Hall, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Antiguo o usado
Soft cover
Librería: killarneybooks, Inagh, CLARE, Irlanda
Calificación del vendedor: 5 de 5 estrellas
Soft cover. Condición: Very Good. 2nd Edition. Oversized paperback, second edition, xviii + 324 pages, NOT ex-library. Limited gentle handling wear only. Book is clean and bright throughout with unmarked text, free of inscriptions and stamps, firmly bound. -- Contents [each chapter contains Introduction & Further Reading & Exercises & Bibliography]: Introduction; PART I Network Motifs 1. Transcription Networks: Basic Concepts [Cognitive Problem of the Cell; Elements of Transcription Networks; Dynamics and Response Time of Simple Regulation] 2 Autoregulation: A Network Motif [Patterns, Randomized Networks and Network Motifs; Autoregulation Is a Network Motif; Negative Autoregulation Speeds the Response Time of Gene Circuits; Negative Autoregulation Promotes Robustness to Fluctuations in Production Rate; Summary: Evolution as an Engineer] 3. Feedforward Loop Network Motif [Feedforward Loop Is a Network Motif; Structure of the Feedforward Loop Gene Circuit; Dynamics of the Coherent Type-1 FFL with AND Logic; C1-FFL Is a Sign-Sensitive Delay Element; OR-Gate C1-FFL Is a Sign-Sensitive Delay for OFF Steps; Incoherent Type-1 FFL Generates Pulses of Output; Other Six FFL Types Can Also Act as Filters and Pulse Generators; Convergent Evolution of FFLS; Summary] 4 Temporal Programs and the Global Structure of Transcription Networks [Single-Input Module (SIM) Network Motif; SIM Can Generate Temporal Gene Expression Programs; Multi-Output Feedforward Loop; Multi-Output FFL Can Generate FIFO Temporal Programs; Signal Integration by Bi-Fans and Dense-Overlapping Regulons; Network Motifs and the Global Structure of Sensory Transcription Networks; Interlocked Feedforward Loops in the B. subtilis Sporulation Network] 5 Positive Feedback, Bistability and Memory 6 How to Build a Biological Oscillator; PART II Robustness -- 7 Kinetic Proofreading and Conformational Proofreading [Kinetic Proofreading of the Genetic Code Can Reduce Error Rates; Recognition of Self and Non-Self by the Immune System; Kinetic Proofreading Occurs in Diverse Processes in the Cell; Conformational Proofreading Provides Speci?city without Consuming Energy; Demand Rules for Gene Regulation Can Minimize Errors] 8 Robust Signaling by Bifunctional Components 9 Robustness in Bacterial Chemotaxis [Bacterial Chemotaxis, or How Bacteria Think; Chemotaxis Protein Circuit; Barkai-Leibler Model of Exact Adaptation; Individuality and Robustness in Bacterial Chemotaxis] 10 Fold-Change Detection [Universal Features of Sensory Systems; Fold-Change Detection in Bacterial Chemotaxis; FCD and Exact Adaptation; Incoherent Feedforward Loop Can Show FCD; General Condition for FCD; Identifying FCD Circuits from Dynamic Measurements; FCD Provides Robustness to Input Noise and Allows Scale-Invariant Searches] 11 Dynamical Compensation and Mutant Resistance in Tissues 12 Robust Spatial Patterning in Development [French Flag Model Is Not Robust; Increased Robustness by Self-Enhanced Morphogen Degradation; Network Motifs That Provide Degradation Feedback for Robust Patterning; Robustness Principle Can Distinguish between Mechanisms of Fruit Fly Patterning]; PART III Optimality -- 13 Optimal Gene Circuit Design 14 Multi-Objective Optimality in Biology [Fitness Landscape Picture for a Single Task; Multiple Tasks Are Characterized by Performance Functions; Pareto Optimality in Performance Space & in Trait Space Leads to Simple Patterns; Two Tasks Lead to a Line Segment, Three Tasks to a Triangle, Four to a Tetrahedron; Trade-Offs in Morphology; Archetypes Can Last over Geological Timescales; Trade-Offs for Proteins; Trade-Offs in Gene Expression; Division of Labor in the Individual Cells That Make Up an Organ; Variation within a Species Lies on the Pareto Front] 15 Modularity; APPENDIX A Input Functions of Genes: Michaelis-Menten and Hill Equations B Multi-Dimensional Input Functions C Graph Properties of Transcription Networks D Noise in Gene Expression; Index. Nº de ref. del artículo: 010916
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An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Computational Biology Series)
Publicado por
Chapman And Hall/Crc, 2020
ISBN 10: 1439837171
ISBN 13: 9781439837177
Antiguo o usado
Tapa blanda
Librería: Anybook.com, Lincoln, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Condición: Poor. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. In poor condition, suitable as a reading copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,850grams, ISBN:9781439837177. Nº de ref. del artículo: 5829811
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Introduction to Systems Biology : Design Principles of Biological Circuits
Publicado por
Chapman and Hall/CRC, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Antiguo o usado
Tapa blanda
Librería: GreatBookPrices, Columbia, MD, Estados Unidos de America
Calificación del vendedor: 5 de 5 estrellas
Condición: As New. Unread book in perfect condition. Nº de ref. del artículo: 18926320
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An Introduction to Systems Biology: Design Principles of Biological Circuits
Publicado por
Taylor & Francis Inc, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Nuevo
Paperback / softback
Librería: THE SAINT BOOKSTORE, Southport, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Paperback / softback. Condición: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days. Nº de ref. del artículo: C9781439837177
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An Introduction to Systems Biology: Design Principles of Biological Circuits
Publicado por
Taylor & Francis Inc, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Nuevo
Paperback / softback
Librería: THE SAINT BOOKSTORE, Southport, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Paperback / softback. Condición: New. New copy - Usually dispatched within 4 working days. 712. Nº de ref. del artículo: B9781439837177
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An Introduction to Systems Biology
Publicado por
Taylor & Francis Group, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Nuevo
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Librería: Majestic Books, Hounslow, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Condición: New. pp. 324. Nº de ref. del artículo: 49603538
Cantidad disponible: 3 disponibles
Imagen de archivo
An Introduction to Systems Biology (Chapman & Hall/CRC Computational Biology Series)
Publicado por
Chapman and Hall/CRC, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Nuevo
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Librería: California Books, Miami, FL, Estados Unidos de America
Calificación del vendedor: 5 de 5 estrellas
Condición: New. Nº de ref. del artículo: I-9781439837177
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Introduction to Systems Biology : Design Principles of Biological Circuits
Publicado por
Chapman and Hall/CRC, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Nuevo
Tapa blanda
Librería: GreatBookPricesUK, Woodford Green, Reino Unido
Calificación del vendedor: 5 de 5 estrellas
Condición: New. Nº de ref. del artículo: 18926320-n
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Imagen de archivo
An Introduction to Systems Biology (Chapman & Hall/CRC Computational Biology Series)
Publicado por
Chapman and Hall/CRC, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Antiguo o usado
Tapa blanda
Librería: SecondSale, Montgomery, IL, Estados Unidos de America
Calificación del vendedor: 4 de 5 estrellas
Condición: Good. Item in good condition. Textbooks may not include supplemental items i.e. CDs, access codes etc. Nº de ref. del artículo: 00089275816
Cantidad disponible: 1 disponibles
Imagen de archivo
An Introduction to Systems Biology (Chapman & Hall/CRC Computational Biology Series)
Publicado por
Chapman and Hall/CRC, 2019
ISBN 10: 1439837171
ISBN 13: 9781439837177
Antiguo o usado
Tapa blanda
Librería: SecondSale, Montgomery, IL, Estados Unidos de America
Calificación del vendedor: 4 de 5 estrellas
Condición: Very Good. Item in very good condition! Textbooks may not include supplemental items i.e. CDs, access codes etc. Nº de ref. del artículo: 00087332792
Cantidad disponible: 1 disponibles