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An Introduction to Single Molecule Biophysics (Foundations of Biochemistry and Biophysics) - Tapa dura

Libro 4 de 11: Foundations of Biochemistry and Biophysics
 
9781439806944: An Introduction to Single Molecule Biophysics (Foundations of Biochemistry and Biophysics)
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ISBN 10: 1439806942 ISBN 13: 9781439806944
Editorial: CRC Press, 2017

Sinopsis

This book gives an accessible, detailed overview on techniques of single molecule biophysics (SMB), showing how they are applied to numerous biological problems associated with understanding the molecular mechanisms of DNA replication, transcription, and translation, as well as functioning of molecular machines. It covers major single molecule imaging and probing techniques, highlighting key strengths and limitations of each method using recent examples. The chapters begin with a discussion of single molecule fluorescence techniques followed by an overview of the atomic force microscope and its use for direct time-lapse visualization of dynamics of molecular complexes at the nanoscale, as well as applications in measurements of interactions between molecules and mechanical properties of isolated molecules and their complexes. The next chapters address magnetic tweezers and optical tweezers, including instrumentation, fundamentals of operation, and applications. A final chapter turns to nanopore transport and nanopore-based DNA sequencing technology that will play a major role in next-generation genomics and healthcare applications.

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Acerca del autor

Yuri L. Lyubchenko is Professor of Pharmaceutical Sciences at the University of Nebraska Medical Center, Omaha, NE, USA. His research focuses on understanding fundamental mechanisms underlying health and disease, which are key to developing new and more effective diagnostics and medications. This primarily basic research allows him not only identify new drug targets for small molecule drugs, it also leads to development of the nanotools and methods to discover novel approaches for diagnostic, treatment, and disease prevention, and to more rapidly determine their efficacy at the molecular level.

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Editorial
CRC Press
Año de publicación
2017
Idioma
Inglés
ISBN 10 
1439806942
ISBN 13 
9781439806944
Encuadernación
Tapa dura
Número de edición
1
Número de páginas
250
Editor
Lyubchenko Yuri L.
Contacto del fabricante
Taylor and Francis, GPSR Taylor and Francis
gpsr@taylorandfrancis.com

Taylor & Francis Verlag GmbH, Kaufingerstraße 24
München
80331
Alemania