Artículos relacionados a Metal Complex–DNA Interactions

Metal Complex–DNA Interactions - Tapa dura

Hadjiliadis, N

 
9781405176293: Metal Complex–DNA Interactions
Tapa dura
ISBN 10: 1405176296 ISBN 13: 9781405176293
Editorial: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd), 2009

Sinopsis

Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:*Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models. *Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.*DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.* Toxicological Aspects: deals with structural studies of mercury-DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity. This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.

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Acerca del autor

Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.

De la contraportada

The importance of metal-DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today.


This book provides an overview of metal-DNA interactions, the mechanism of their interaction, metal-based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal-based drugs.

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Editorial
Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
Año de publicación
2009
Idioma
Inglés
ISBN 10 
1405176296
ISBN 13 
9781405176293
Encuadernación
Tapa dura
Número de páginas
544
Contacto del fabricante
no disponible
Persona responsable
no disponible