The Principles of Pathologic Histology (Classic Reprint) - Tapa blanda

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Excerpt from The Principles of Pathologic Histology

This book treats of pathology from the morphologic point of view. The aim constantly in mind has been to present the subject biologically, first by ascertaining so far as possible the cellular elements out of which the various lesions are built up, and then by tracing the development of the lesions from the simplest to the most complex.

The principle followed may be stated in another way. In order to understand an end result such as sclerosis of an organ or tissue (for instance, cirrhosis of the liver or chronic nephritis) it is necessary to find and study all the various acute lesions which may terminate in sclerosis. Frequently much the same end result may be produced in several different ways. Once the complete development of the various lesions has been traced, then the final result becomes more intelligible, so that we are often able in a given instance to surmise or even to state definitely how it arose. In other words, we are in a position to read the process backward with some degree of certainty.

The morphologic side of pathology is difficult for many students to comprehend. To them it is a dead subject. They cannot read the cell changes going on and visualize them into an active process. Moreover, it requires patience often extending over many years to collect the tissues most suitable for study and for teaching purposes. Even then, with the pathologic problems made as simple as possible by having perfect tissues, perfect fixation, and the best of stained sections, the lesions are not always easy to read and to interpret. On the other hand, recourse to animal experimentation has often served to confuse a subject rather than to simplify and clear it up.

In pathology the lesions themselves are the original sources of information. It is necessary to keep going back to them in order, by means of constantly improved technic, to reinterpret the changes which are taking place. The literature of a pathologic subject represents the history of the study, understanding, and interpretation of the lesions. It is much less important than the study of the lesions themselves. Hence, not the literature of a pathologic subject, but perfect tissue, fixed and stained by the best methods, affords the greatest opportunities for advance.

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