Artículos relacionados a Statistical Methods for Survival Trial Design: With...

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics Series) - Tapa dura

Libro 90 de 155: Chapman & Hall/CRC Biostatistics

Wu, Jianrong

 
9781138033221: Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics Series)
Tapa dura
ISBN 10: 1138033227 ISBN 13: 9781138033221
Editorial: Chapman and Hall/CRC, 2018

Sinopsis

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials.

This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

"Sinopsis" puede pertenecer a otra edición de este libro.

Acerca del autor

Jianrong (John) Wu is a professor in the Division of Cancer Biostatistics, Department of Biostatistics, Markey Cancer Center, University of Kentucky. He has more than 15 years’ experience of designing and conducting cancer clinical trials at St. Jude Children’s Research Hospital and has developed several novel statistical methods for designing phase II and phase III survival trials.

De la contraportada

This book focuses on clinical trial design and monitoring with time-to-event endpoints. Detail of subjects of the book are included in book contents. This book not only provides a comprehensive review of existing methods. The book also presents a general group sequential method for trial monitoring which has not been published in any book.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Chapman and Hall/CRC
Año de publicación
2018
Idioma
Inglés
ISBN 10 
1138033227
ISBN 13 
9781138033221
Encuadernación
Tapa dura
Número de edición
1
Número de páginas
257
Contacto del fabricante
no disponible
Persona responsable
no disponible