This practical high-level guidebook offers an in-depth understanding of the newly emerging clinical trial designs in adaptive trial designs and master protocols. Both concise and readable without shying away from technical discussion, the book introduces the most innovative approaches in clinical trial research such as adaptive trial designs, master protocols, platform trial, basket trial, and umbrella trial designs. Featuring a revisionist history of clinical research before moving on to case-study based discussion and practical considerations from collective experience. The book enables readers to understand the strengths and limitations of these novel designs as well as their application to individual areas of research and clinical practice. Supplemented by real-world examples from the recent developments in medical research efficiency instigated by both personalized medicine and high-profile diseases like COVID-19 and cancer. The first book of its kind, it is the go-to resource for medical students and researchers working in clinical trial research.
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Jay J. H. Park is an Assistant Professor in the Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences at McMaster University in Canada.
Edward J. Mills is a Professor in the Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences at McMaster University in Canada.
J. Kyle Wathen is Vice President of Scientific Strategy and Innovation at Cytel Inc.
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