DNA-Encoded Chemical Libraries: Methods and Protocols: 2541 (Methods in Molecular Biology, 2541) - Tapa dura

Libro 157 de 381: Methods in Molecular Biology
 
9781071625446: DNA-Encoded Chemical Libraries: Methods and Protocols: 2541 (Methods in Molecular Biology, 2541)
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ISBN 10: 1071625446 ISBN 13: 9781071625446
Editorial: Humana, 2022

Sinopsis

This volume discusses protocols that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries: Methods and Protocols is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.


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De la contraportada

This volume discusses protocols that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries: Methods and Protocols is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Humana
Año de publicación
2022
Idioma
Inglés
ISBN 10 
1071625446
ISBN 13 
9781071625446
Encuadernación
Tapa dura
Número de edición
1
Número de páginas
238
Editor
Israel David, Ding Yun
Contacto del fabricante
Springer Nature Customer Service Center GmbH
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Europaplatz 3,69115 Heidelberg, Germany
Heidelberg
69115
Alemania

Otras ediciones populares con el mismo título

9781071625477: DNA-Encoded Chemical Libraries: Methods and Protocols: 2541 (Methods in Molecular Biology)

Edición Destacada

ISBN 10:  1071625470 ISBN 13:  9781071625477
Editorial: Humana, 2023
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