Cerebral Ischemia: Molecular and Cellular Pathophysiology (Contemporary Neuroscience) - Tapa dura

 
9780896035409: Cerebral Ischemia: Molecular and Cellular Pathophysiology (Contemporary Neuroscience)
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ISBN 10: 0896035409 ISBN 13: 9780896035409
Editorial: Humana Press, 1999

Sinopsis

The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aerobic metabolism. This high dependency on energy-consuming processes is mainly caused by the active transport of ions, which is necessary to compensate for the transmembrane ion currents that are part ofthe complex signaling processes in the brain. Ninety-five percent ofthe brain’s ATP is derived from mitochondrial oxidative phosphorylation. Since that organ’ s storage capacity for oxygen is minimal, any interruption of oxygen delivery to brain cells willlead to changes in membrane excitability and, there­ fore, to disruption of neuronal signaling within seconds. It seems that mamma­ lian brain is especially vulnerable to such an interruption, since oxygen deprivation leads to activation of ion channel mechanisms in neurons that impair their communications. Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption. Oxygen delivery depends on two variables described in the Fick relation­ ship: volume flow rate ofblood and the arterial oxygen content. A reduction in either of these two variables will have serious effects on vital brain func­ tions. Reduction of arterial blood flow to the brain can be caused by cardiac arrest, shock, carotid occlusion, Of hypotension (global ischemia). Oxygen content is progressively decreased in asphyxia (including drowning).

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De la contraportada

In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions.
Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today.

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Editorial
Humana Press
Año de publicación
1999
Idioma
Inglés
ISBN 10 
0896035409
ISBN 13 
9780896035409
Encuadernación
Tapa dura
Número de páginas
292
Editor
Walz Wolfgang
Contacto del fabricante
no disponible
Persona responsable
no disponible

Otras ediciones populares con el mismo título

9781475747355: Cerebral Ischemia: Molecular and Cellular Pathophysiology (Contemporary Neuroscience)

Edición Destacada

ISBN 10:  1475747357 ISBN 13:  9781475747355
Editorial: Humana, 2013
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