Telomeres: Monograph 29 (Cold Spring Harbor Monograph Series) - Tapa dura

Reseña del editor

Research on telomeres has recently surged forward. Telomeres have been found to shorten in neoplastic and aging cells, and their analysis has been stimulated by the molecular cloning of key components in telomere metabolism. This book offers a comprehensive account of telomere structure and function in a variety of organisms, including yeast, Drosophila, ciliates, plants and mammals. Starting with a historical overview, it covers telomere structure, dynamics, localization, transcriptional silencing, as well as the significance of length regulation and the roles of telomeres. Written and edited by members of leading laboratories, the book should be of use to investigators of cancer and aging, as well as those with interests in replication, ribonuclear particles, chromosome dynamics and polymerases.