Synapses, the sites where neurons communicate with other cells, are where most of the drugs known to affect brain function act. The analysis of synaptic function and architecture is central to understanding how the nervous system works and how drug therapies exert their effects. It also has important implications for the study of learning and memory, of neural development, and, more generally, for the clinical disciplines of neurology and psychiatry. This volume provides a comprehensive overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field, the text should be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters and synaptic morphology. It should also be a useful reference for students and biomedical professionals in all areas of neuroscience.
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W. Maxwell Cowan recently retired as the vice president and chief scientific officer at the Howard Hughes Medical Institute (HHMI), Chevy Chase, Maryland. Born and raised in South Africa, Dr. Cowan received his D. Phil from Oxford University and served on the faculty at Oxford before moving to the United States. He was affiliated with Washington University, St.Louis, for 15 years before joining the Salk Institute, where he served as Vice President. In 1986, Dr Cowan returned to Washington University to become Provost and Executive Vice Chancellor. He joined the Howard Hughes Medical Institute in 1988. Dr. Cowan is a Fellow of the Royal Society and a Foreign Associate of the National Academy of Sciences. Thomas C. Sudhof is an HHMI investigator and professor of molecular genetics at the University of Texas Southwestern Medical Center at Dallas. He obtained postdoctoral training first with Victor Whittaker at the Max Planck Institute for Biophysical Chemistry, Gottingen, and then with Michael Brown and Joseph Goldstein in Dallas. Charles F. Stevens is an HHMI investigator at the Salk Institute for Biological Studies and adjunct professor of Pharmacology and of Neuroscience at the University of California, San Diego, School of Medicine. Dr. Stevens is a member of the National Academy of Sciences.
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