T Cell Subsets in Infectious and Autoimmune Diseases (Ciba Foundation Symposium) - Tapa dura

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Mature T cells are classified on the basis of their surface marker proteins, such as CD4 and CD8. CD4⁺ and CD8⁺ cells recognize antigens associated with major histocompatibility complex class II and class I molecules, respectively, and they can both be further classified into subgroups. The division of CD4⁺ T cells into T helper 1 (Th1) and Th2 cells is based on the secretion of distinct patterns of cytokines, and the resulting polarized Th1 and Th2 responses play different roles in protection and the promotion of different immunopathological reactions. In contrast, CD8⁺ T cells are strongly cytotoxic; however, they can also secrete Th1-like or Th2-like cytokine profiles. This suggests that there is an increasingly complex network of cytokine regulatory patterns which are produced in response to, and specifically tailored to, different offending agents. This book contains contributions from a diverse group of scientists and clinicians working on T cells. Specific topics include: the differentiation and regulation of T cell subsets; their roles in bacterial, protozoan, viral and autoimmune diseases; and the effector mechanisms employed by these subsets of cells. Vaccine development, memory, anergy and allergy are also discussed.