Toxicogenomics: Principles and Applications - Tapa dura

Acerca del autor

Dr. Hisham K. Hamadeh is a research scientist at Amgen. He earned his Ph.D. in toxicology from the University of California at Irvine, following up as a research fellow in the National Center for Toxicogenomics Microarray Center, NIEHS. He has received research excellence awards from the Society of Toxicology and American Cancer Society.

Dr. Cynthia A. Afshari is Associate Director of Toxicology at Amgen. She has served as Director of Basic Research Applications at the Microarray Center and Head of the Gene Regulation Group, Laboratory of Molecular Carcinogenesis, NIEHS. She has also held a position as adjunct professor for the Curriculum in Toxicology at the University of North Carolina, Chapel Hill.

De la contraportada

With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice. This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response of living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application.

Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technologies in genomics, proteomics, metabonomics, and bioinformatics, as well as their applications to toxicology research. Coverage includes:

• A general introduction to toxicology for nonspecialists
• Microarray/high-density gene expression profiling
• Quantitative RNA measurement
• Analysis of metabolites (metabonomics)
• Statistics and databases for toxicogenomics
• Functional genomics models
• Protein analysis and profiling

Throughout Toxicogenomics, the emphasis remains on information practitioners can put to use immediately. Numerous illustrations support the text, and a helpful summary lists key software and Internet tools, as well as additional resources. Written for specialists and nonspecialists alike, Toxicogenomics gives a wide range of researchers access to the unique combination of disciplines that characterize this exciting new field.