Compendium of Organic Synthetic Methods, Volume 11 - Tapa dura

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MICHAEL B. SMITH, PhD, is Professor of Chemistry at the University of Connecticut at Storrs. His research interests focus on developing asymmetric reactions based on manipulating chiral, nonracemic lactams. This work is applied to the development of new synthetic methods and the synthesis of polycyclic alkaloids with antitumor or antiviral activity. Dr. Smith is responsible for developing a new reagent for determining the enantiomeric composition of alcohols and amines bearing a chiral center.

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New protocols for functional group transformations and carbon-carbon bond-forming reactions

The Compendium of Organic Synthetic Methods series facilitates the working chemist?s search for the most useful functional group transformations in organic chemistry. Drawn from an exhaustive survey of the literature from 1999, 2000, and 2001, Compendium of Organic Synthetic Methods, Volume 11 contains both functional group transformations and carbon-carbon bond-forming reactions, as well as a chapter devoted exclusively to difunctional compounds. Author Michael Smith adheres to stringent criteria for listing reactions, including real synthetic utility and reagents that are either readily available or easily prepared and handled in the laboratory.

Among many other subjects, Volume 11 covers:

• Acid derivatives and anhydrides
• Alcohols
• Alkyls, methylenes, and aryls
• Amides
• Ethers, epoxides, and thioethers
• Halides and sulfonates
• Hydrides
• Alkenes

Volume 11 presents 2,781 examples of published reactions for the preparation of monofunctional compounds, updating the 13,050 examples in volumes 1?10. It also contains 1,212 examples of reactions for preparing difunctional compounds within various functional groups, and adds forty-one pertinent reviews, long a feature of this series, in various sections. A useful alphabetical list of all cited authors follows Chapter 16.

A clear organizational scheme?? chemical transformations classified first by reacting functional group of starting material, then by functional group formed?? allows for quick reference and information retrieval. In addition, helpful indices for mono- and difunctional compounds efficiently guide the user to specific classes of transformations.

Compendium of Organic Synthetic Methods, Volume 11 provides an unparalleled source of information on the methods, reactions, and transformations in contemporary organic chemistry for the working chemist and student alike.