Linker Strategies in Solid-Phase Organic Synthesis - Tapa dura

Sinopsis

LINKER DESIGN IS AN EXPANDING FIELD WITH AN EXCITING FUTURE IN STATE–OF–THE–ART ORGANIC SYNTHESIS. EVER–INCREASING NUMBERS OF AMBITIOUS SOLUTION PHASE REACTIONS ARE BEING ADAPTED FOR SOLID–PHASE ORGANIC CHEMISTRY AND TO ACCOMMODATE THEM, LARGE NUMBERS OF SOPHISTICATED LINKER UNITS HAVE BEEN DEVELOPED AND ARE NOW ROUTINELY EMPLOYED IN SOLID–PHASE SYNTHESIS. LINKER STRATEGIES IN SOLID–PHASE ORGANIC SYNTHESIS GUIDES THE READER THROUGH THE EVOLUTION OF LINKER UNITS FROM THEIR GENESIS IN SOLID–SUPPORTED PEPTIDE CHEMISTRY TO THE CUTTING EDGE DIVERSITY LINKER UNITS THAT ARE DEFINING A NEW ERA OF SOLID PHASE SYNTHESIS.  INDIVIDUAL LINKER CLASSES ARE COVERED IN EASY TO FOLLOW CHAPTERS WRITTEN BY INTERNATIONAL EXPERTS IN THEIR RESPECTIVE FIELDS AND OFFER A COMPREHENSIVE GUIDE TO LINKER TECHNOLOGY WHILST SIMULTANEOUSLY SERVING AS A HANDBOOK OF SYNTHETIC TRANSFORMATIONS NOW POSSIBLE ON SOLID SUPPORTS. TOPICS INCLUDE: THE PRINCIPLES OF SOLID PHASE ORGANIC SYNTHESIS ELECTROPHILE AND NUCLEOPHILE CLEAVABLE LINKER UNITS CYCLATIVE CLEAVAGE AS A SOLID PHASE STRATEGY PHOTOCLEAVABLE LINKER UNITS SAFETY–CATCH LINKER UNITS ENZYME CLEAVABLE LINKER UNITS T1 AND T2 VERSATILE TRIAZENE LINKER GROUPS HYDRAZONE LINKER UNITS BENZOTRIAZOLE LINKER UNITS PHOSPHORUS LINKER UNITS SULFUR LINKER UNITS SELENIUM AND TELLURIUM LINKER UNITS SULFUR, OXYGEN AND SELENIUM LINKER UNITS CLEAVED BY RADICAL PROCESSES SILICON AND GERMANIUM LINKER UNITS BORON AND STANNANE LINKER UNITS BISMUTH LINKER UNITS TRANSITION METAL CARBONYL LINKER UNITS LINKERS RELEASING OLEFINS OR CYCLOOLEFINS BY RING–CLOSING METATHESIS FLUOROUS LINKER UNITS SOLID–PHASE RADIOCHEMISTRY THE BOOK CONCLUDES WITH EXTENSIVE LINKER SELECTION TABLES, CATALOGUING THE LINKER

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