Targeting Protein Kinases for Cancer Therapy

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9780470229651: Targeting Protein Kinases for Cancer Therapy

An expert guide to targeting protein kinases in cancer therapy

Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication.

Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes:

  • Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research

  • Focus on small molecule inhibitors as well as other therapeutic modalities

  • Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market

Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.

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About the Author:

DAVID J. MATTHEWS is Executive Director of Oncology Discovery at Exelixis, where he is responsible for cancer drug discovery. For more than fifteen years, Dr. Matthews has been involved in drug discovery projects in industry, with particular focus on small molecule inhibitors. He has twenty scientific publications and multiple patents to his credit.

MARY E. GERRITSEN is Vice President of Molecular and Cellular Pharmacology at Exelixis, where she is in charge of cell-based screening in preclinical research and of biomarker studies for clinical development compounds in Phase I and II studies. Her prior industry experience includes positions at Genentech, Bayer and Millennium Pharmaceuticals. She has authored more than one hundred peer-reviewed articles and twenty-six book chapters and is an inventor on forty-two issued patents.

Review:

"This excellent book is a comprehensive review of protein kinases in the context of their roles in human cancer. ... [It] is an excellent resource for scientists involved in selecting potential drug targets and optimization of compounds that are likely to be effective. The involvement of protein kinases in cancer, and strategies for selecting drug targets is thoughtfully discussed, and protein structures, domains and sites of regulation are described in depth and in ways that are easy to follow and understand. Individual kinases are described from the biological perspective and in the context of efforts to target them, often with case studies to illustrate specific points in exquisite detail. Understanding these proteins at this level of detail is essential to understand how they can be targeted and what we can expect to observe in the clinic. Following description of the kinases themselves and their function and regulation in signaling pathways, and cell cycle control, the second half of this book describes kinase inhibitors and experience gained from analyzing these compounds in vitro and in vivo. The final chapter addresses challenges and future directions, including issues relating to combinational therapy and systems biology. These big issues complete the comprehensive tour of the world of kinases in the context of cancer, from molecular details of drug-protein interactions, through biology to clinical application. Considering the success so far in targeting these enzymes in the clinic, and the level of investment currently being made to developing new kinase inhibitors for cancer therapy, there is no doubt that this outstanding book will be a valuable asset to the large community of chemists, biologists and clinicians involved in developing the next generation of therapies."
Frank McCormick, Director, UCSF Helen Diller Family Comprehensive Cancer Center

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David J. Matthews; Mary E. Gerritsen
Editorial: Wiley (2010)
ISBN 10: 0470229659 ISBN 13: 9780470229651
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Descripción John Wiley and Sons Ltd, United States, 2010. Hardback. Estado de conservación: New. 1. Auflage. Language: English . Brand New Book. This book provides an overview of different protein kinases structure, function, regulation, and their role in cancer. Itcombines kinase biology with chemistry and pharmacologyapplications for discovery and development of cancer drugs. Thetext also describes existing and emerging kinase inhibitors,focusing mostly on small molecules but also alternative approacheslike therapeutic antibodies. Provides an important resource thathelps pharmaceutical researchers understand and work in thisdynamic area of cancer drug research. Nº de ref. de la librería AAH9780470229651

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Descripción John Wiley and Sons Ltd, United States, 2010. Hardback. Estado de conservación: New. 1. Auflage. Language: English . Brand New Book. This book provides an overview of different protein kinases structure, function, regulation, and their role in cancer. Itcombines kinase biology with chemistry and pharmacologyapplications for discovery and development of cancer drugs. Thetext also describes existing and emerging kinase inhibitors,focusing mostly on small molecules but also alternative approacheslike therapeutic antibodies. Provides an important resource thathelps pharmaceutical researchers understand and work in thisdynamic area of cancer drug research. Nº de ref. de la librería AAH9780470229651

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Descripción John Wiley and Sons Ltd. Hardback. Estado de conservación: new. BRAND NEW, Targeting Protein Kinases for Cancer Therapy, David J. Matthews, Mary E. Gerritsen, This book provides an overview of different protein kinases structure, function, regulation, and their role in cancer. Itcombines kinase biology with chemistry and pharmacologyapplications for discovery and development of cancer drugs. Thetext also describes existing and emerging kinase inhibitors,focusing mostly on small molecules but also alternative approacheslike therapeutic antibodies. Provides an important resource thathelps pharmaceutical researchers understand and work in thisdynamic area of cancer drug research. Nº de ref. de la librería B9780470229651

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Descripción John Wiley and Sons Ltd, United States, 2010. Hardback. Estado de conservación: New. 1. Auflage. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. This book provides an overview of different protein kinases structure, function, regulation, and their role in cancer. Itcombines kinase biology with chemistry and pharmacologyapplications for discovery and development of cancer drugs. Thetext also describes existing and emerging kinase inhibitors,focusing mostly on small molecules but also alternative approacheslike therapeutic antibodies. Provides an important resource thathelps pharmaceutical researchers understand and work in thisdynamic area of cancer drug research. Nº de ref. de la librería BZV9780470229651

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Descripción John Wiley & Sons Inc, 2010. Hardcover. Estado de conservación: Brand New. 1st edition. 702 pages. 9.25x6.25x1.75 inches. In Stock. Nº de ref. de la librería __0470229659

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