Bioinformatics and Functional Genomics

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9780470085851: Bioinformatics and Functional Genomics

The bestselling introduction to bioinformatics and functional genomics—now in an updated edition

Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

  • Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions.
  • A completely updated companion web site, which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics
  • Descriptions of genome sequencing projects spanning the tree of life.
  • A stronger focus on how bioinformatics tools are used to understand human disease.

The book is complemented by lavish illustrations and more than 500 figures and tables—fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Praise for the first edition:

"...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology

"... an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering

"...highly recommended for academic and medical libraries, and for researchers as an introduction and reference..." E-Streams

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From the Publisher:

"I was particularly impressed by the comprehensible and comprehensive treatment of BLAST - the best that I have seen. One is guided from choosing the appropriate type of BLAST program, database and search parameters through to refining and analysing the significance of the search results--all illustrated with clear examples." (David P. Leader, University of Glasgow)

From the Author:

Bioinformatics and Functional Genomics is a textbook for advanced undergraduate students, graduate students, and anyone involved in biomedical research. Bioinformatics represents a new field at the interface of the twentieth century revolutions in molecular biology and computers. A focus of this new discipline is the use of computer databases and computer algorithms to study proteins, genes, and the complete collections of genes that comprise an organism (genomes). A major challenge in biology is to make sense of the enormous quantities of sequence data and structural data that are being generated by genome sequencing projects and other molecular biology efforts. The tools of bioinformatics include computer programs that help to reveal fundamental mechanisms underlying biological problems related to the structure and function of macromolecules, biochemical pathways, disease processes, and evolution. The aim of the book is to explain both the theory and practice of bioinformatics and genomics. The book is especially designed to help the biologist use computer programs and databases to solve biological problems.

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